Ulcerative necrobiosis lipoidica responsive to colchicine

ABSTRACT Necrobiosis lipoidica is an uncommon granulomatous disease of unknown aetiology. Few treatments have emerged with consistent efficacy and the ulcerated form of necrobiosis lipoidica can be particularly difficult to treat. A 56‐year‐old non‐diabetic woman with chronic ulcerative necrobiosis...

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Veröffentlicht in:	Australasian journal of dermatology 2012-08, Vol.53 (3), p.e54-e57
Hauptverfasser:	Schofield, Clare, Sladden, Michael J
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents - therapeutic use colchicine Colchicine - therapeutic use Female Humans Middle Aged necrobiosis lipoidica Necrobiosis Lipoidica - complications Necrobiosis Lipoidica - drug therapy nuclear factor‐κB Skin Ulcer - etiology tumour necrosis factor‐α ulcerative necrobiosis lipoidica
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Zusammenfassung:	ABSTRACT Necrobiosis lipoidica is an uncommon granulomatous disease of unknown aetiology. Few treatments have emerged with consistent efficacy and the ulcerated form of necrobiosis lipoidica can be particularly difficult to treat. A 56‐year‐old non‐diabetic woman with chronic ulcerative necrobiosis lipoidica unresponsive to other therapies was commenced on colchicine treatment. Complete resolution of the ulcers was observed after 2 months therapy with colchicine 500 µg twice daily.
ISSN:	0004-8380 1440-0960
DOI:	10.1111/j.1440-0960.2011.00768.x