Obesity, But Not High-Fat Diet, Promotes Murine Pancreatic Cancer Growth

Background Obesity accelerates pancreatic cancer growth; the mechanisms underlying this association are poorly understood. This study evaluated the hypothesis that obesity, rather than high-fat diet, is responsible for accelerated pancreatic cancer growth. Methods Male C57BL/6J mice were studied after 19 weeks of high-fat (60 % fat; n = 20) or low-fat (10 % fat; n = 10) diet and 5 weeks of Pan02 murine pancreatic cancer growth (flank). Results By two-way ANOVA, diet did not ( p = 0.58), but body weight, significantly influenced tumor weight ( p = 0.01). Tumor weight correlated positively with body weight ( R 2 = 0.562; p