Stimulatory effect of SOM230 on human and rat adrenal corticosteroid secretion in vitro

Stimulatory effect of SOM230 on human and rat adrenal corticosteroid secretion in vitro

Highlights ► SOM230 is a newly developed somatostatin analog acting on multiple receptor subtypes. ► We investigated its action on human and rat adrenal corticosteroid secretion. ► Unexpectedly, SOM230 stimulated corticosteroid secretion in vitro . ► The effect of SOM230 on the adrenal supports diff...

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Veröffentlicht in:General and comparative endocrinology 2012-09, Vol.178 (2), p.436-439
Hauptverfasser: Pecori Giraldi, F, Pagliardini, L, Cassarino, M.F, Martucci, F, Sesta, A, Castelli, L, Montanari, E, Schmid, H.A, Cavagnini, F
Format: Artikel
Sprache:eng
Schlagworte:
Adrenal Glands - drug effects
Adrenal Glands - secretion
Animals
Cells, Cultured
Corticosterone
Corticosterone - secretion
corticotropin
Cortisol
Cushing’s syndrome
dose response
Endocrinology & Metabolism
Humans
neoplasms
patients
Rats
secretion
SOM230
Somatostatin
Somatostatin - agonists
Somatostatin - analogs & derivatives
Somatostatin - pharmacology
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Zusammenfassung:Highlights ► SOM230 is a newly developed somatostatin analog acting on multiple receptor subtypes. ► We investigated its action on human and rat adrenal corticosteroid secretion. ► Unexpectedly, SOM230 stimulated corticosteroid secretion in vitro . ► The effect of SOM230 on the adrenal supports differences from other somatostatin analogs.
ISSN:0016-6480
1095-6840
DOI:10.1016/j.ygcen.2012.05.003