Pseudocholinesterase in gestational diabetes: positive correlation with LDL and negative correlation with triglyceride

Objective Low pseudocholinesterase (PChE) activity accompanies pregnancy, liver disease, renal failure, and certain drug therapies. The aim of this study was to investigate a possible relationship among PChE and plasma insulin levels, lipid profile, and inflammatory response in gestational diabetes. Methods This study included 165 women aged 20–40 years. Subjects were divided into four groups as follows: Control group, 29 non-pregnant healthy women; Group NGT, 61 healthy pregnant women (normal glucose tolerance); Group GD, 62 pregnant women with gestational diabetes; and Group AGT, 13 pregnant women with abnormal glucose tolerance. Gestational ages were between 34 and 40 weeks. Plasma PChE, triglyceride, high-/low-density lipoprotein (HDL, LDL), glycated hemoglobin A1c (HbA 1c ), insulin, C-reactive protein (CRP), and white blood cell (WBC) levels were measured in all subjects. Results There were no statistically significant differences in plasma PChE, insulin, and LDL levels between the groups. Plasma triglyceride, HbA 1c , WBC, and CRP levels were significantly higher in Group GD and Group AGT compared to the other groups ( P