Thyroid hormones are involved in 5′-nucleotidase modulation in soluble fraction of cardiac tissue

Thyroid hormones are involved in 5′-nucleotidase modulation in soluble fraction of cardiac tissue

To investigate the role of TH (thyroid hormones) in 5′-nucleotidase activity and expression in cardiac soluble fraction (SF). Male Wistar rats received daily injections of T4 (10, 25 or 50μg T4/100g body weight) for 14days to develop a hyperthyroidism condition. Thyroidectomy was performed in other...

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Veröffentlicht in:Life sciences (1973) 2012-08, Vol.91 (3-4), p.137-142
Hauptverfasser: Cotomacci, Guilherme, Sarkis, João J.F., Fürstenau, Cristina R., Barreto-Chaves, Maria Luiza M.
Format: Artikel
Sprache:eng
Schlagworte:
5'-Nucleotidase - metabolism
5′-Nucleotidase
Adenosine
Animals
Blood Pressure
Body Weight
cardiac output
cardioprotective effect
Gene Expression Regulation
Hemodynamics
Hyperthyroidism
Hyperthyroidism - metabolism
Hypothyroidism
Hypothyroidism - metabolism
Male
Models, Biological
Myocardium - metabolism
Nucleotides - chemistry
protein kinase C
Protein Kinase C - metabolism
protein synthesis
Rats
Rats, Wistar
Solubility
Soluble cardiac subcellular fraction
Subcellular Fractions - metabolism
surgery
thyroid hormones
Thyroid Hormones - metabolism
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Zusammenfassung:To investigate the role of TH (thyroid hormones) in 5′-nucleotidase activity and expression in cardiac soluble fraction (SF). Male Wistar rats received daily injections of T4 (10, 25 or 50μg T4/100g body weight) for 14days to develop a hyperthyroidism condition. Thyroidectomy was performed in other animals to mimic hypothyroidism, and 14days after surgery they were submitted to TH replacement therapy. T4 reduced the 5′-nucleotidase activity (T4-25, P
ISSN:0024-3205
1879-0631
DOI:10.1016/j.lfs.2012.06.023