Co-regulation of survival of motor neuron and Bcl-xL expression: Implications for neuroprotection in spinal muscular atrophy

Highlights ► Expression of SMN and Bcl-xL is co-regulated. ► Bcl-xL levels are increased in PrP-SMN transgenic mouse brains. ► SMN and Bcl-xL expression reduce Sam68 levels. ► Co-expression of SMN and Bcl-xL additively protects against apoptosis. ► Exogenous SMN expression increases endogenous FL-SM...

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Veröffentlicht in:	Neuroscience 2012-09, Vol.220, p.228-236
Hauptverfasser:	Anderton, R.S, Price, L.L, Turner, B.J, Meloni, B.P, Mitrpant, C, Mastaglia, F.L, Goh, C, Wilton, S.D, Boulos, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism additive Animals bcl-X Protein - metabolism Bcl-xL Biological and medical sciences Blotting, Western Cell Line co-expression Fundamental and applied biological sciences. Psychology Gene Expression Regulation Humans Mice Mice, Transgenic Motor Neurons - metabolism Muscular Atrophy, Spinal - metabolism Neurology PrP-SMN Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA-Binding Proteins - metabolism Sam68 SMN Survival of Motor Neuron 1 Protein - metabolism Transduction, Genetic Vertebrates: nervous system and sense organs
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Zusammenfassung:	Highlights ► Expression of SMN and Bcl-xL is co-regulated. ► Bcl-xL levels are increased in PrP-SMN transgenic mouse brains. ► SMN and Bcl-xL expression reduce Sam68 levels. ► Co-expression of SMN and Bcl-xL additively protects against apoptosis. ► Exogenous SMN expression increases endogenous FL-SMN transcript levels.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2012.06.042