Influence Of Magnetic Iron Oxide Nanoparticles And Perfluoroalkylated Amphiphilic Phosphates On Red Blood Cells And Caco-2 Cells

The interactions of two types of cells (red blood cells (RBCs), Caco-2 cells) with magnetic iron oxide nanoparticles (non-grafted, citrate-grafted, dendrimer-grafted) of 11 nm in size, and with three perfluoroalkylated amphiphilic phosphates varying in chain length and number of fluorine atoms have been investigated. We focused on two important physiological parameters of the cells, the intracellular pH and the intracellular Ca(2+) content. The results show that the nanoparticles do not have a significant influence on the pH and Ca(2+) content of Caco-2 cells. The Ca(2+) content of RBCs is also not affected but the intracellular pH is slightly reduced. In addition, the perfluoroalkylated phosphates do not affect the Caco-2 cells. However, these molecules have a small effect on the intracellular pH of RBCs. Furthermore, they influence significantly the Ca(2+) content of a subpopulation of the RBCs.