Gonadotropin signalling in epithelial ovarian cancer

Ovarian cancer is the most lethal of all gynecologic malignancies, although its aetiology remains poorly understood. A role for the gonadotropins, follicle-stimulating hormone (FSH) and luteinising hormone (LH), has been implicated in a variety of different aspects of ovarian cancer tumorigenesis, i...

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Veröffentlicht in:	Cancer letters 2012-11, Vol.324 (2), p.152-159
Hauptverfasser:	Mertens-Walker, Inga, Baxter, Robert C, Marsh, Deborah J
Format:	Artikel
Sprache:	eng
Schlagworte:	animal ovaries Animals Antineoplastic Agents, Hormonal - metabolism Antineoplastic Agents, Hormonal - therapeutic use carcinogenesis Carcinoma, Ovarian Epithelial cell proliferation etiology Female Follicle Stimulating Hormone - metabolism follicle-stimulating hormone FSH gene expression Gonadotropins Gonadotropins - genetics Gonadotropins - metabolism Hematology, Oncology and Palliative Medicine Humans Infertility Ligands luteinizing hormone Luteinizing Hormone - metabolism Medical research Menopause Mortality Neoplasms, Glandular and Epithelial - drug therapy Neoplasms, Glandular and Epithelial - genetics Neoplasms, Glandular and Epithelial - metabolism Neoplasms, Glandular and Epithelial - pathology Ovarian cancer ovarian neoplasms Ovarian Neoplasms - drug therapy Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Receptors, Gonadotropin - metabolism Signal Transduction - drug effects Signalling pathways Studies
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Beschreibung
Zusammenfassung:	Ovarian cancer is the most lethal of all gynecologic malignancies, although its aetiology remains poorly understood. A role for the gonadotropins, follicle-stimulating hormone (FSH) and luteinising hormone (LH), has been implicated in a variety of different aspects of ovarian cancer tumorigenesis, including cellular proliferation, migration and invasion. This review focuses on the latest advances in knowledge concerning signalling pathways and functional consequences of gonadotropin action, including changes in protein-, miRNA- and gene expression, in epithelial ovarian cancer cells.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2012.05.017