In silico design, synthesis and evaluation of 3'-O-benzylated analogs of salacinol, a potent α-glucosidase inhibitor isolated from an Ayurvedic traditional medicine "Salacia"
With the aid of an in silico method, α-glucosidase inhibitors with far more potent activities than salacinol (1), a potent natural α-glucosidase inhibitor isolated from an Ayurvedic traditional medicine Salacia reticulata, have been developed.
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2012-09, Vol.48 (69), p.8646-8648 |
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| container_end_page | 8648 |
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| container_issue | 69 |
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| container_title | Chemical communications (Cambridge, England) |
| container_volume | 48 |
| creator | Tanabe, Genzoh Nakamura, Shinya Tsutsui, Nozomi Balakishan, Gorre Xie, Weijia Tsuchiya, Satoshi Akaki, Junji Morikawa, Toshio Ninomiya, Kiyofumi Nakanishi, Isao Yoshikawa, Masayuki Muraoka, Osamu |
| description | With the aid of an in silico method, α-glucosidase inhibitors with far more potent activities than salacinol (1), a potent natural α-glucosidase inhibitor isolated from an Ayurvedic traditional medicine Salacia reticulata, have been developed. |
| doi_str_mv | 10.1039/c2cc34144a |
| format | Article |
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| identifier | ISSN: 1359-7345 |
| ispartof | Chemical communications (Cambridge, England), 2012-09, Vol.48 (69), p.8646-8648 |
| issn | 1359-7345 1364-548X |
| language | eng |
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| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | alpha-Glucosidases - chemistry alpha-Glucosidases - metabolism Animals Drug Design Enzyme Inhibitors - chemistry Enzyme Inhibitors - isolation & purification Enzyme Inhibitors - pharmacology Glycoside Hydrolase Inhibitors Humans Hypoglycemic Agents - chemistry Hypoglycemic Agents - isolation & purification Hypoglycemic Agents - pharmacology Models, Molecular Plant Extracts - chemistry Plant Extracts - isolation & purification Plant Extracts - pharmacology Rats Salacia - chemistry Structure-Activity Relationship Sugar Alcohols - chemistry Sugar Alcohols - isolation & purification Sugar Alcohols - pharmacology Sulfates - chemistry Sulfates - isolation & purification Sulfates - pharmacology |
| title | In silico design, synthesis and evaluation of 3'-O-benzylated analogs of salacinol, a potent α-glucosidase inhibitor isolated from an Ayurvedic traditional medicine "Salacia" |
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