In silico design, synthesis and evaluation of 3'-O-benzylated analogs of salacinol, a potent α-glucosidase inhibitor isolated from an Ayurvedic traditional medicine "Salacia"

With the aid of an in silico method, α-glucosidase inhibitors with far more potent activities than salacinol (1), a potent natural α-glucosidase inhibitor isolated from an Ayurvedic traditional medicine Salacia reticulata, have been developed.

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2012-09, Vol.48 (69), p.8646-8648
Hauptverfasser:	Tanabe, Genzoh, Nakamura, Shinya, Tsutsui, Nozomi, Balakishan, Gorre, Xie, Weijia, Tsuchiya, Satoshi, Akaki, Junji, Morikawa, Toshio, Ninomiya, Kiyofumi, Nakanishi, Isao, Yoshikawa, Masayuki, Muraoka, Osamu
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Glucosidases - chemistry alpha-Glucosidases - metabolism Animals Drug Design Enzyme Inhibitors - chemistry Enzyme Inhibitors - isolation & purification Enzyme Inhibitors - pharmacology Glycoside Hydrolase Inhibitors Humans Hypoglycemic Agents - chemistry Hypoglycemic Agents - isolation & purification Hypoglycemic Agents - pharmacology Models, Molecular Plant Extracts - chemistry Plant Extracts - isolation & purification Plant Extracts - pharmacology Rats Salacia - chemistry Structure-Activity Relationship Sugar Alcohols - chemistry Sugar Alcohols - isolation & purification Sugar Alcohols - pharmacology Sulfates - chemistry Sulfates - isolation & purification Sulfates - pharmacology
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Beschreibung
Zusammenfassung:	With the aid of an in silico method, α-glucosidase inhibitors with far more potent activities than salacinol (1), a potent natural α-glucosidase inhibitor isolated from an Ayurvedic traditional medicine Salacia reticulata, have been developed.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c2cc34144a