Proinflammatory and oxidative stress markers in patients submitted to Roux-en-Y gastric bypass after 1 year of follow-up
BACKGROUND/OBJECTIVES: This study examined the effect of weight loss after 3, 6 and 12 months of Roux-en-Y Gastric Bypass (RYGB) on energy intake and on several biomarkers of oxidative stress such as levels of vitamin C, beta-carotene, vitamin E (diet/blood), nitric oxide metabolites (NOx), myeloper...
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| Veröffentlicht in: | European journal of clinical nutrition 2012-08, Vol.66 (8), p.891-899 |
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| creator | da Silva, V R G Moreira, E A M Wilhelm-Filho, D de Miranda, J X Benincá, J P Vigil, S V G Moratelli, A M B Garlet, T R de Souza Meirelles, M S Vannucchi, H Fröde, T S |
| description | BACKGROUND/OBJECTIVES:
This study examined the effect of weight loss after 3, 6 and 12 months of Roux-en-Y Gastric Bypass (RYGB) on energy intake and on several biomarkers of oxidative stress such as levels of vitamin C, beta-carotene, vitamin E (diet/blood), nitric oxide metabolites (NOx), myeloperoxidase (MPO), thiobarbituric acid reactive substances (TBARS), reduced glutathione (GSH) and activity of catalase (CAT).
SUBJECTS/METHODS:
Study with a control group (CG), assessed once, and a bariatric group (BG) assessed at the basal period as well as at 3, 6 and 12 months post-surgery; both groups were composed of 5 men and 31 women (
n
=36). Age was 38.7±9.4 and 39.6±9.2 years old and body mass index (BMI) was 22.2±2.1 and 47.6±9.1 kg/m
2
, respectively. The variance measure quoted was SEM.
RESULTS:
The body weight at 12 months was 35.8±1.0% (
P |
| doi_str_mv | 10.1038/ejcn.2012.17 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1031156514</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A299759860</galeid><sourcerecordid>A299759860</sourcerecordid><originalsourceid>FETCH-LOGICAL-c589t-fdaeb4fb8560c7c5940d7e110d810a7360fa94c2f9c29250f64d19b7ac68b6bf3</originalsourceid><addsrcrecordid>eNp9ks9vFCEUxydGY2v15tmQGI0HZwVmgOHYNP5KmmiMHjxNGOaxZWVgC4zu_vey6eq2ZmM4kPA-3_fgy7eqnhK8ILjp3sBK-wXFhC6IuFedklbwmvEW369OsWRt3WAsTqpHKa0wLkVBH1YnlDaskZSfVpvPMVhvnJomlUPcIuVHFDZ2VNn-BJRyhJTQpOIPiAlZj9alAD4nlOZhsjnDiHJAX8K8qcHX39FSFY3VaNiuVVEqkyEigragIgoGmeBc-FXP68fVA6Ncgif7_az69u7t14sP9eWn9x8vzi9rzTqZazMqGFozdIxjLTSTLR4FEILHjmAlGo6Nkq2mRmoqKcOGtyORg1CadwMfTHNWvbrpu47heoaU-8kmDc4pD2FOffGQEMYZaQv6_B90Feboy-16ylvKGW06_j-q9MKidGvpgVoqB31xOOSo9G50f06lFEx2HBeqPkItwUNULngwthzf4RdH-LJGmKw-Knh5S3AFyuWrFNycbfDpLvj6BtQxpBTB9Otoy7dvy6N27-r6Xc76Xc56Igr-bG9CSQGMf-E_wSrAiz2gklbOROW1TQeOE8loyw4OpFLyS4i33Twy-Ddx5ueC</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1030711542</pqid></control><display><type>article</type><title>Proinflammatory and oxidative stress markers in patients submitted to Roux-en-Y gastric bypass after 1 year of follow-up</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>da Silva, V R G ; Moreira, E A M ; Wilhelm-Filho, D ; de Miranda, J X ; Benincá, J P ; Vigil, S V G ; Moratelli, A M B ; Garlet, T R ; de Souza Meirelles, M S ; Vannucchi, H ; Fröde, T S</creator><creatorcontrib>da Silva, V R G ; Moreira, E A M ; Wilhelm-Filho, D ; de Miranda, J X ; Benincá, J P ; Vigil, S V G ; Moratelli, A M B ; Garlet, T R ; de Souza Meirelles, M S ; Vannucchi, H ; Fröde, T S</creatorcontrib><description><![CDATA[BACKGROUND/OBJECTIVES:
This study examined the effect of weight loss after 3, 6 and 12 months of Roux-en-Y Gastric Bypass (RYGB) on energy intake and on several biomarkers of oxidative stress such as levels of vitamin C, beta-carotene, vitamin E (diet/blood), nitric oxide metabolites (NOx), myeloperoxidase (MPO), thiobarbituric acid reactive substances (TBARS), reduced glutathione (GSH) and activity of catalase (CAT).
SUBJECTS/METHODS:
Study with a control group (CG), assessed once, and a bariatric group (BG) assessed at the basal period as well as at 3, 6 and 12 months post-surgery; both groups were composed of 5 men and 31 women (
n
=36). Age was 38.7±9.4 and 39.6±9.2 years old and body mass index (BMI) was 22.2±2.1 and 47.6±9.1 kg/m
2
, respectively. The variance measure quoted was SEM.
RESULTS:
The body weight at 12 months was 35.8±1.0% (
P
<0.001) lower than that of the basal period. At the basal period BG showed higher levels of NOx (
P
=0.007) and TBARS (
P
<0.001) and lower levels of vitamins C and E (
P
<0.001) compared with CG. After 3 months the activity of MPO was decreased (
P
<0.001). Six months after surgery GSH levels were decreased (
P
=0.037), whereas CAT activity was increased (
P
=0.029). After 12 months levels of NOx (
P
=0.004), TBARS (
P
<0.001), beta-carotene (
P
<0.001) and vitamin E (
P
<0.001) were decreased, whereas those of vitamin C (
P
<0.001) were increased compared with controls.
CONCLUSION:
RYGB followed by a daily vitamin supplement apparently attenuated pro-inflammatory and oxidative stress markers 1 year after surgery, but additional antioxidant supplementation appears necessary.]]></description><identifier>ISSN: 0954-3007</identifier><identifier>EISSN: 1476-5640</identifier><identifier>DOI: 10.1038/ejcn.2012.17</identifier><identifier>PMID: 22353926</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/53 ; 692/700/459/1994 ; 692/700/565/545/2098 ; Adult ; Antioxidants ; Antioxidants - administration & dosage ; Ascorbic acid ; Ascorbic Acid - administration & dosage ; Ascorbic Acid - blood ; beta Carotene - administration & dosage ; beta Carotene - blood ; Biological and medical sciences ; Biomarkers ; Biomarkers - blood ; Blood ; Body Mass Index ; Body size ; Body weight ; Body weight loss ; Carotene ; Case-Control Studies ; Catalase ; Catalase - blood ; Clinical Nutrition ; Complications and side effects ; Development and progression ; Diet ; Dietary Supplements ; Energy Intake ; Epidemiology ; Feeding. Feeding behavior ; Female ; Follow-Up Studies ; Fundamental and applied biological sciences. Psychology ; Gastric bypass ; Gastric Bypass - methods ; Gastrointestinal surgery ; Glutathione ; Glutathione - blood ; Health aspects ; Humans ; Inflammation ; Inflammation - physiopathology ; Inflammation - therapy ; Internal Medicine ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Metabolites ; Middle Aged ; Nitric oxide ; Obesity ; original-article ; Oxidative Stress ; Peroxidase ; Peroxidase - blood ; Physiological aspects ; Prospective Studies ; Public Health ; Stomach, duodenum, intestine, rectum, anus ; Surgery ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the digestive system ; Thiobarbituric acid ; Thiobarbituric Acid Reactive Substances - analysis ; Thiobarbituric Acid Reactive Substances - metabolism ; Tocopherol ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vitamin C ; Vitamin E ; Vitamin E - administration & dosage ; Vitamin E - blood ; Vitamins ; Weight Loss ; β-Carotene</subject><ispartof>European journal of clinical nutrition, 2012-08, Vol.66 (8), p.891-899</ispartof><rights>Macmillan Publishers Limited 2012</rights><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2012 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Aug 2012</rights><rights>Macmillan Publishers Limited 2012.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c589t-fdaeb4fb8560c7c5940d7e110d810a7360fa94c2f9c29250f64d19b7ac68b6bf3</citedby><cites>FETCH-LOGICAL-c589t-fdaeb4fb8560c7c5940d7e110d810a7360fa94c2f9c29250f64d19b7ac68b6bf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26195245$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22353926$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>da Silva, V R G</creatorcontrib><creatorcontrib>Moreira, E A M</creatorcontrib><creatorcontrib>Wilhelm-Filho, D</creatorcontrib><creatorcontrib>de Miranda, J X</creatorcontrib><creatorcontrib>Benincá, J P</creatorcontrib><creatorcontrib>Vigil, S V G</creatorcontrib><creatorcontrib>Moratelli, A M B</creatorcontrib><creatorcontrib>Garlet, T R</creatorcontrib><creatorcontrib>de Souza Meirelles, M S</creatorcontrib><creatorcontrib>Vannucchi, H</creatorcontrib><creatorcontrib>Fröde, T S</creatorcontrib><title>Proinflammatory and oxidative stress markers in patients submitted to Roux-en-Y gastric bypass after 1 year of follow-up</title><title>European journal of clinical nutrition</title><addtitle>Eur J Clin Nutr</addtitle><addtitle>Eur J Clin Nutr</addtitle><description><![CDATA[BACKGROUND/OBJECTIVES:
This study examined the effect of weight loss after 3, 6 and 12 months of Roux-en-Y Gastric Bypass (RYGB) on energy intake and on several biomarkers of oxidative stress such as levels of vitamin C, beta-carotene, vitamin E (diet/blood), nitric oxide metabolites (NOx), myeloperoxidase (MPO), thiobarbituric acid reactive substances (TBARS), reduced glutathione (GSH) and activity of catalase (CAT).
SUBJECTS/METHODS:
Study with a control group (CG), assessed once, and a bariatric group (BG) assessed at the basal period as well as at 3, 6 and 12 months post-surgery; both groups were composed of 5 men and 31 women (
n
=36). Age was 38.7±9.4 and 39.6±9.2 years old and body mass index (BMI) was 22.2±2.1 and 47.6±9.1 kg/m
2
, respectively. The variance measure quoted was SEM.
RESULTS:
The body weight at 12 months was 35.8±1.0% (
P
<0.001) lower than that of the basal period. At the basal period BG showed higher levels of NOx (
P
=0.007) and TBARS (
P
<0.001) and lower levels of vitamins C and E (
P
<0.001) compared with CG. After 3 months the activity of MPO was decreased (
P
<0.001). Six months after surgery GSH levels were decreased (
P
=0.037), whereas CAT activity was increased (
P
=0.029). After 12 months levels of NOx (
P
=0.004), TBARS (
P
<0.001), beta-carotene (
P
<0.001) and vitamin E (
P
<0.001) were decreased, whereas those of vitamin C (
P
<0.001) were increased compared with controls.
CONCLUSION:
RYGB followed by a daily vitamin supplement apparently attenuated pro-inflammatory and oxidative stress markers 1 year after surgery, but additional antioxidant supplementation appears necessary.]]></description><subject>692/53</subject><subject>692/700/459/1994</subject><subject>692/700/565/545/2098</subject><subject>Adult</subject><subject>Antioxidants</subject><subject>Antioxidants - administration & dosage</subject><subject>Ascorbic acid</subject><subject>Ascorbic Acid - administration & dosage</subject><subject>Ascorbic Acid - blood</subject><subject>beta Carotene - administration & dosage</subject><subject>beta Carotene - blood</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Blood</subject><subject>Body Mass Index</subject><subject>Body size</subject><subject>Body weight</subject><subject>Body weight loss</subject><subject>Carotene</subject><subject>Case-Control Studies</subject><subject>Catalase</subject><subject>Catalase - blood</subject><subject>Clinical Nutrition</subject><subject>Complications and side effects</subject><subject>Development and progression</subject><subject>Diet</subject><subject>Dietary Supplements</subject><subject>Energy Intake</subject><subject>Epidemiology</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastric bypass</subject><subject>Gastric Bypass - methods</subject><subject>Gastrointestinal surgery</subject><subject>Glutathione</subject><subject>Glutathione - blood</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammation - physiopathology</subject><subject>Inflammation - therapy</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Metabolites</subject><subject>Middle Aged</subject><subject>Nitric oxide</subject><subject>Obesity</subject><subject>original-article</subject><subject>Oxidative Stress</subject><subject>Peroxidase</subject><subject>Peroxidase - blood</subject><subject>Physiological aspects</subject><subject>Prospective Studies</subject><subject>Public Health</subject><subject>Stomach, duodenum, intestine, rectum, anus</subject><subject>Surgery</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the digestive system</subject><subject>Thiobarbituric acid</subject><subject>Thiobarbituric Acid Reactive Substances - analysis</subject><subject>Thiobarbituric Acid Reactive Substances - metabolism</subject><subject>Tocopherol</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Vitamin C</subject><subject>Vitamin E</subject><subject>Vitamin E - administration & dosage</subject><subject>Vitamin E - blood</subject><subject>Vitamins</subject><subject>Weight Loss</subject><subject>β-Carotene</subject><issn>0954-3007</issn><issn>1476-5640</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9ks9vFCEUxydGY2v15tmQGI0HZwVmgOHYNP5KmmiMHjxNGOaxZWVgC4zu_vey6eq2ZmM4kPA-3_fgy7eqnhK8ILjp3sBK-wXFhC6IuFedklbwmvEW369OsWRt3WAsTqpHKa0wLkVBH1YnlDaskZSfVpvPMVhvnJomlUPcIuVHFDZ2VNn-BJRyhJTQpOIPiAlZj9alAD4nlOZhsjnDiHJAX8K8qcHX39FSFY3VaNiuVVEqkyEigragIgoGmeBc-FXP68fVA6Ncgif7_az69u7t14sP9eWn9x8vzi9rzTqZazMqGFozdIxjLTSTLR4FEILHjmAlGo6Nkq2mRmoqKcOGtyORg1CadwMfTHNWvbrpu47heoaU-8kmDc4pD2FOffGQEMYZaQv6_B90Feboy-16ylvKGW06_j-q9MKidGvpgVoqB31xOOSo9G50f06lFEx2HBeqPkItwUNULngwthzf4RdH-LJGmKw-Knh5S3AFyuWrFNycbfDpLvj6BtQxpBTB9Otoy7dvy6N27-r6Xc76Xc56Igr-bG9CSQGMf-E_wSrAiz2gklbOROW1TQeOE8loyw4OpFLyS4i33Twy-Ddx5ueC</recordid><startdate>20120801</startdate><enddate>20120801</enddate><creator>da Silva, V R G</creator><creator>Moreira, E A M</creator><creator>Wilhelm-Filho, D</creator><creator>de Miranda, J X</creator><creator>Benincá, J P</creator><creator>Vigil, S V G</creator><creator>Moratelli, A M B</creator><creator>Garlet, T R</creator><creator>de Souza Meirelles, M S</creator><creator>Vannucchi, H</creator><creator>Fröde, T S</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20120801</creationdate><title>Proinflammatory and oxidative stress markers in patients submitted to Roux-en-Y gastric bypass after 1 year of follow-up</title><author>da Silva, V R G ; Moreira, E A M ; Wilhelm-Filho, D ; de Miranda, J X ; Benincá, J P ; Vigil, S V G ; Moratelli, A M B ; Garlet, T R ; de Souza Meirelles, M S ; Vannucchi, H ; Fröde, T S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c589t-fdaeb4fb8560c7c5940d7e110d810a7360fa94c2f9c29250f64d19b7ac68b6bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>692/53</topic><topic>692/700/459/1994</topic><topic>692/700/565/545/2098</topic><topic>Adult</topic><topic>Antioxidants</topic><topic>Antioxidants - administration & dosage</topic><topic>Ascorbic acid</topic><topic>Ascorbic Acid - administration & dosage</topic><topic>Ascorbic Acid - blood</topic><topic>beta Carotene - administration & dosage</topic><topic>beta Carotene - blood</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Blood</topic><topic>Body Mass Index</topic><topic>Body size</topic><topic>Body weight</topic><topic>Body weight loss</topic><topic>Carotene</topic><topic>Case-Control Studies</topic><topic>Catalase</topic><topic>Catalase - blood</topic><topic>Clinical Nutrition</topic><topic>Complications and side effects</topic><topic>Development and progression</topic><topic>Diet</topic><topic>Dietary Supplements</topic><topic>Energy Intake</topic><topic>Epidemiology</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastric bypass</topic><topic>Gastric Bypass - methods</topic><topic>Gastrointestinal surgery</topic><topic>Glutathione</topic><topic>Glutathione - blood</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Inflammation - physiopathology</topic><topic>Inflammation - therapy</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Metabolites</topic><topic>Middle Aged</topic><topic>Nitric oxide</topic><topic>Obesity</topic><topic>original-article</topic><topic>Oxidative Stress</topic><topic>Peroxidase</topic><topic>Peroxidase - blood</topic><topic>Physiological aspects</topic><topic>Prospective Studies</topic><topic>Public Health</topic><topic>Stomach, duodenum, intestine, rectum, anus</topic><topic>Surgery</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the digestive system</topic><topic>Thiobarbituric acid</topic><topic>Thiobarbituric Acid Reactive Substances - analysis</topic><topic>Thiobarbituric Acid Reactive Substances - metabolism</topic><topic>Tocopherol</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Vitamin C</topic><topic>Vitamin E</topic><topic>Vitamin E - administration & dosage</topic><topic>Vitamin E - blood</topic><topic>Vitamins</topic><topic>Weight Loss</topic><topic>β-Carotene</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>da Silva, V R G</creatorcontrib><creatorcontrib>Moreira, E A M</creatorcontrib><creatorcontrib>Wilhelm-Filho, D</creatorcontrib><creatorcontrib>de Miranda, J X</creatorcontrib><creatorcontrib>Benincá, J P</creatorcontrib><creatorcontrib>Vigil, S V G</creatorcontrib><creatorcontrib>Moratelli, A M B</creatorcontrib><creatorcontrib>Garlet, T R</creatorcontrib><creatorcontrib>de Souza Meirelles, M S</creatorcontrib><creatorcontrib>Vannucchi, H</creatorcontrib><creatorcontrib>Fröde, T S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>da Silva, V R G</au><au>Moreira, E A M</au><au>Wilhelm-Filho, D</au><au>de Miranda, J X</au><au>Benincá, J P</au><au>Vigil, S V G</au><au>Moratelli, A M B</au><au>Garlet, T R</au><au>de Souza Meirelles, M S</au><au>Vannucchi, H</au><au>Fröde, T S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Proinflammatory and oxidative stress markers in patients submitted to Roux-en-Y gastric bypass after 1 year of follow-up</atitle><jtitle>European journal of clinical nutrition</jtitle><stitle>Eur J Clin Nutr</stitle><addtitle>Eur J Clin Nutr</addtitle><date>2012-08-01</date><risdate>2012</risdate><volume>66</volume><issue>8</issue><spage>891</spage><epage>899</epage><pages>891-899</pages><issn>0954-3007</issn><eissn>1476-5640</eissn><abstract><![CDATA[BACKGROUND/OBJECTIVES:
This study examined the effect of weight loss after 3, 6 and 12 months of Roux-en-Y Gastric Bypass (RYGB) on energy intake and on several biomarkers of oxidative stress such as levels of vitamin C, beta-carotene, vitamin E (diet/blood), nitric oxide metabolites (NOx), myeloperoxidase (MPO), thiobarbituric acid reactive substances (TBARS), reduced glutathione (GSH) and activity of catalase (CAT).
SUBJECTS/METHODS:
Study with a control group (CG), assessed once, and a bariatric group (BG) assessed at the basal period as well as at 3, 6 and 12 months post-surgery; both groups were composed of 5 men and 31 women (
n
=36). Age was 38.7±9.4 and 39.6±9.2 years old and body mass index (BMI) was 22.2±2.1 and 47.6±9.1 kg/m
2
, respectively. The variance measure quoted was SEM.
RESULTS:
The body weight at 12 months was 35.8±1.0% (
P
<0.001) lower than that of the basal period. At the basal period BG showed higher levels of NOx (
P
=0.007) and TBARS (
P
<0.001) and lower levels of vitamins C and E (
P
<0.001) compared with CG. After 3 months the activity of MPO was decreased (
P
<0.001). Six months after surgery GSH levels were decreased (
P
=0.037), whereas CAT activity was increased (
P
=0.029). After 12 months levels of NOx (
P
=0.004), TBARS (
P
<0.001), beta-carotene (
P
<0.001) and vitamin E (
P
<0.001) were decreased, whereas those of vitamin C (
P
<0.001) were increased compared with controls.
CONCLUSION:
RYGB followed by a daily vitamin supplement apparently attenuated pro-inflammatory and oxidative stress markers 1 year after surgery, but additional antioxidant supplementation appears necessary.]]></abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>22353926</pmid><doi>10.1038/ejcn.2012.17</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0954-3007 |
| ispartof | European journal of clinical nutrition, 2012-08, Vol.66 (8), p.891-899 |
| issn | 0954-3007 1476-5640 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1031156514 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | 692/53 692/700/459/1994 692/700/565/545/2098 Adult Antioxidants Antioxidants - administration & dosage Ascorbic acid Ascorbic Acid - administration & dosage Ascorbic Acid - blood beta Carotene - administration & dosage beta Carotene - blood Biological and medical sciences Biomarkers Biomarkers - blood Blood Body Mass Index Body size Body weight Body weight loss Carotene Case-Control Studies Catalase Catalase - blood Clinical Nutrition Complications and side effects Development and progression Diet Dietary Supplements Energy Intake Epidemiology Feeding. Feeding behavior Female Follow-Up Studies Fundamental and applied biological sciences. Psychology Gastric bypass Gastric Bypass - methods Gastrointestinal surgery Glutathione Glutathione - blood Health aspects Humans Inflammation Inflammation - physiopathology Inflammation - therapy Internal Medicine Male Medical sciences Medicine Medicine & Public Health Metabolic Diseases Metabolites Middle Aged Nitric oxide Obesity original-article Oxidative Stress Peroxidase Peroxidase - blood Physiological aspects Prospective Studies Public Health Stomach, duodenum, intestine, rectum, anus Surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the digestive system Thiobarbituric acid Thiobarbituric Acid Reactive Substances - analysis Thiobarbituric Acid Reactive Substances - metabolism Tocopherol Vertebrates: anatomy and physiology, studies on body, several organs or systems Vitamin C Vitamin E Vitamin E - administration & dosage Vitamin E - blood Vitamins Weight Loss β-Carotene |
| title | Proinflammatory and oxidative stress markers in patients submitted to Roux-en-Y gastric bypass after 1 year of follow-up |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-21T09%3A48%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Proinflammatory%20and%20oxidative%20stress%20markers%20in%20patients%20submitted%20to%20Roux-en-Y%20gastric%20bypass%20after%201%20year%20of%20follow-up&rft.jtitle=European%20journal%20of%20clinical%20nutrition&rft.au=da%20Silva,%20V%20R%20G&rft.date=2012-08-01&rft.volume=66&rft.issue=8&rft.spage=891&rft.epage=899&rft.pages=891-899&rft.issn=0954-3007&rft.eissn=1476-5640&rft_id=info:doi/10.1038/ejcn.2012.17&rft_dat=%3Cgale_proqu%3EA299759860%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1030711542&rft_id=info:pmid/22353926&rft_galeid=A299759860&rfr_iscdi=true |