Association of total iron binding capacity with coronary artery disease

A case–control study and a meta-analysis were conducted to assess the association between total iron binding capacity (TIBC) and coronary artery disease (CAD) risk. A hospital-based case–control study was conducted with 258 CAD cases and 282 healthy controls. Logistic regression was utilized to estimate odds ratio (OR) with 95% confidence interval (CI) and adjust potential confounders. Dose–response relation was investigated between TIBC and CAD risk by dividing TIBC concentration into quartiles. A meta-analysis was performed on the standardized mean difference (SMD) as well as OR. In our case–control study, TIBC was found associated with decreased CAD risk both in univariate (OR=0.981, 95% CI=0.975, 0.986) and multivariate (OR=0.979, 95% CI=0.972, 0.986) adjusted logistic regressions. The multivariate-adjusted OR for the highest quartile compared with the lowest quartile was 0.087 (95% CI=0.042, 0.181). After sensitivity analysis, the meta-analysis on SMD showed that TIBC was associated with decreased CAD risk (SMD=−0.211, 95% CI=−0.318, −0.104). The results of pooled measure on OR (OR=0.970, 95% CI=0.946, 0.995) were consistent with those of SMD analysis. A weak association was found between TIBC levels and decreased CAD risk, further investigations are necessary to clarify the dose–response relationship. ► Association of TIBC and CAD risk was explored. ► We conducted a case–control study and a meta-analysis. ► A weak association was found between TIBC levels and decreased CAD risk.