MicroRNA-375 targets AEG-1 in hepatocellular carcinoma and suppresses liver cancer cell growth in vitro and in vivo

MicroRNAs (miRNAs) are believed to have fundamental roles in tumorigenesis and have great potential for the diagnosis and treatment of cancer. However, the roles of miRNAs in hepatocellular carcinogenesis are still not fully elucidated. We investigated the aberrantly expressed miRNAs involved in hep...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Oncogene 2012-07, Vol.31 (28), p.3357-3369
Hauptverfasser:	He, X-X, Chang, Y, Meng, F-Y, Wang, M-Y, Xie, Q-H, Tang, F, Li, P-Y, Song, Y-H, Lin, J-S
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated regions Animal models Animals Antitumor activity Apoptosis Apoptosis - genetics Astrocytes Bioinformatics Cancer cells Carcinogenesis Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - pathology Care and treatment Cell Adhesion Molecules - genetics Cell Biology Cell growth Cell Line, Tumor Cell migration Cell Proliferation Cell Transformation, Neoplastic Cholesterol Down-Regulation Ectopic expression G1 Phase Cell Cycle Checkpoints - genetics Genetic aspects Hepatocellular carcinoma Hepatocytes Hepatocytes - cytology Hepatocytes - metabolism Hepatocytes - pathology Hepatoma Human Genetics Humans Internal Medicine Liver cancer Liver Neoplasms - genetics Liver Neoplasms - pathology Male Medicine Medicine & Public Health Mice Mice, Inbred BALB C MicroRNA MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism miRNA Molecular modelling Neoplasm Invasiveness - genetics Oncogenes Oncology original-article Phenotypes Physiological aspects Ribonucleic acid RNA RNA-directed DNA polymerase RNA-mediated interference Transcriptome Tumor cell lines Tumorigenesis Western blotting Xenografts
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	MicroRNAs (miRNAs) are believed to have fundamental roles in tumorigenesis and have great potential for the diagnosis and treatment of cancer. However, the roles of miRNAs in hepatocellular carcinogenesis are still not fully elucidated. We investigated the aberrantly expressed miRNAs involved in hepatoma by comparison of miRNA expression profiles in cancerous hepatocytes with normal primary human hepatocytes, and 37 dysregulated miRNAs were screened out by twofold change with a significant difference ( P
ISSN:	0950-9232 1476-5594
DOI:	10.1038/onc.2011.500