Distribution and localisation of Gα proteins in the rostral ventrolateral medulla of normotensive and hypertensive rats: Focus on catecholaminergic neurons

Graphical abstract Highlights ► GPCR signalling via adenylyl cyclase is prominent in the RVLM. ► Gα mRNA abundance is Gαs > Gαi2 > Gαo > Gαq > GαL > Gα11 > Gαi3 > Gαi1 > Gα12 > Gα13 in RVLM. ► Multiple Gα mRNAs reflect a diversity of GPCR inputs to C1, A1 and A5 groups. ►...

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Veröffentlicht in:	Neuroscience 2012-08, Vol.218, p.20-34
Hauptverfasser:	Parker, L.M, Tallapragada, V.J, Kumar, N.N, Goodchild, A.K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylate cyclase Animals Biological and medical sciences Blood pressure Blood Pressure - physiology Brain stem Catecholamines - metabolism Fundamental and applied biological sciences. Psychology G protein-coupled receptors G-proteins Gene expression GTP-Binding Protein alpha Subunits - metabolism Guanine nucleotide-binding protein Homeostasis Immunohistochemistry In Situ Hybridization Medulla oblongata Medulla Oblongata - metabolism Nervous system Neurology Neurons Neurons - metabolism Polymerase chain reaction Rats Rats, Inbred SHR Rats, Inbred WKY Rats, Sprague-Dawley Real-Time Polymerase Chain Reaction Reflexes Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis rostral C1 rostral ventrolateral medulla Signal Transduction - physiology spontaneously hypertensive rat Vertebrates: nervous system and sense organs
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Zusammenfassung:	Graphical abstract Highlights ► GPCR signalling via adenylyl cyclase is prominent in the RVLM. ► Gα mRNA abundance is Gαs > Gαi2 > Gαo > Gαq > GαL > Gα11 > Gαi3 > Gαi1 > Gα12 > Gα13 in RVLM. ► Multiple Gα mRNAs reflect a diversity of GPCR inputs to C1, A1 and A5 groups. ► Catecholaminergic groups in the ventral medulla express Gα mRNAs differentially. ► Gα mRNA distribution is similar in the RVLM of SD, SHR and WKY except Gαs.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2012.05.037