The social defeat animal model of depression shows diminished levels of orexin in mesocortical regions of the dopamine system, and of dynorphin and orexin in the hypothalamus
Highlights ► Orexin was decreased in the dopamine system in social-defeat model of depression. ► Orexin and dynorphin were both decreased in the hypothalamus in this model. ► These neuropeptide changes were seen when the model expressed sexual anhedonia. ► Anhedonia and apathy symptomology were pers...
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| Veröffentlicht in: | Neuroscience 2012-08, Vol.218, p.138-153 |
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| creator | Nocjar, C Zhang, J Feng, P Panksepp, J |
| description | Highlights ► Orexin was decreased in the dopamine system in social-defeat model of depression. ► Orexin and dynorphin were both decreased in the hypothalamus in this model. ► These neuropeptide changes were seen when the model expressed sexual anhedonia. ► Anhedonia and apathy symptomology were persistently shown by the model. ► Chronic defeat crouch behavior predicted hypothalamic orexin loss in this model. |
| doi_str_mv | 10.1016/j.neuroscience.2012.05.033 |
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Psychology ; Hedonic response ; Hypothalamus ; Hypothalamus (lateral) ; Hypothalamus - metabolism ; Intracellular Signaling Peptides and Proteins - biosynthesis ; Male ; mPFC ; Nervous system ; Neurology ; Neuropeptides ; Neuropeptides - biosynthesis ; Nucleus accumbens ; orexin ; Orexins ; Prefrontal Cortex - metabolism ; Radioimmunoassay ; Rats ; Rats, Long-Evans ; Reinforcement ; Social interactions ; Ventral Tegmental Area - metabolism ; Ventral tegmentum ; Vertebrates: nervous system and sense organs ; VTA</subject><ispartof>Neuroscience, 2012-08, Vol.218, p.138-153</ispartof><rights>IBRO</rights><rights>2012 IBRO</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 IBRO. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c564t-1d2ba5780302634a440351af3afd4896336fc1f5f5827aef2e330324c7710b9a3</citedby><cites>FETCH-LOGICAL-c564t-1d2ba5780302634a440351af3afd4896336fc1f5f5827aef2e330324c7710b9a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neuroscience.2012.05.033$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26196221$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22626650$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nocjar, C</creatorcontrib><creatorcontrib>Zhang, J</creatorcontrib><creatorcontrib>Feng, P</creatorcontrib><creatorcontrib>Panksepp, J</creatorcontrib><title>The social defeat animal model of depression shows diminished levels of orexin in mesocortical regions of the dopamine system, and of dynorphin and orexin in the hypothalamus</title><title>Neuroscience</title><addtitle>Neuroscience</addtitle><description>Highlights ► Orexin was decreased in the dopamine system in social-defeat model of depression. ► Orexin and dynorphin were both decreased in the hypothalamus in this model. ► These neuropeptide changes were seen when the model expressed sexual anhedonia. ► Anhedonia and apathy symptomology were persistently shown by the model. ► Chronic defeat crouch behavior predicted hypothalamic orexin loss in this model.</description><subject>Anhedonia</subject><subject>Animal models</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Brain - metabolism</subject><subject>Cortex (prefrontal)</subject><subject>Depression</subject><subject>Depression - metabolism</subject><subject>Disease Models, Animal</subject><subject>Dopamine</subject><subject>Dopamine - metabolism</subject><subject>Dynorphin</subject><subject>Dynorphins - biosynthesis</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hedonic response</subject><subject>Hypothalamus</subject><subject>Hypothalamus (lateral)</subject><subject>Hypothalamus - metabolism</subject><subject>Intracellular Signaling Peptides and Proteins - biosynthesis</subject><subject>Male</subject><subject>mPFC</subject><subject>Nervous system</subject><subject>Neurology</subject><subject>Neuropeptides</subject><subject>Neuropeptides - biosynthesis</subject><subject>Nucleus accumbens</subject><subject>orexin</subject><subject>Orexins</subject><subject>Prefrontal Cortex - metabolism</subject><subject>Radioimmunoassay</subject><subject>Rats</subject><subject>Rats, Long-Evans</subject><subject>Reinforcement</subject><subject>Social interactions</subject><subject>Ventral Tegmental Area - metabolism</subject><subject>Ventral tegmentum</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>VTA</subject><issn>0306-4522</issn><issn>1873-7544</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkl-L1DAUxYso7rj6FaQIgg92zP_O-CDI-hcWfHB9DpnkxmZsm5q0q_1SfkZvZ8ZVfNpSKA2_c0645xbFE0rWlFD1Yr_uYUox2wC9hTUjlK2JXBPO7xQruql5VUsh7hYrwomqhGTsrHiQ857gIwW_X5wxpphSkqyKX1cNlDnaYNrSgQczlqYPHf510UFbRo_HQ4KcQ-zL3MQfuXShC33IDbiyhWto80LFBD9DX-LbAfrFNAaLLgm-ovBAjJjk4mBQjJFzHqF7jmHukDH3MQ0Nqg8HN16LppmHODamNd2UHxb3vGkzPDp9z4sv795eXXyoLj-9_3jx-rKyUomxoo7tjKw3OACmuDBCEC6p8dx4JzZbxbnylnrp5YbVBjwDzglnwtY1Jbut4efFs6PvkOL3CfKou5AttK3pIU5ZU8LQnCsmboMKUddcUURfHlGL7eUEXg8JZ51mhPRSrd7rf6vVS7WaSI1RKH58ypl2Hbgb6Z8uEXh6AkzG0ftkehvyX07RrWJsucWbI4fNwXWApE9xLiSwo3Yx3O4-r_6zsS2uBSZ_gxnyPk6px4o01Rk1-vOyjMsuUkaIUErx30lt4Es</recordid><startdate>20120830</startdate><enddate>20120830</enddate><creator>Nocjar, C</creator><creator>Zhang, J</creator><creator>Feng, P</creator><creator>Panksepp, J</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20120830</creationdate><title>The social defeat animal model of depression shows diminished levels of orexin in mesocortical regions of the dopamine system, and of dynorphin and orexin in the hypothalamus</title><author>Nocjar, C ; Zhang, J ; Feng, P ; Panksepp, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c564t-1d2ba5780302634a440351af3afd4896336fc1f5f5827aef2e330324c7710b9a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Anhedonia</topic><topic>Animal models</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Brain - metabolism</topic><topic>Cortex (prefrontal)</topic><topic>Depression</topic><topic>Depression - metabolism</topic><topic>Disease Models, Animal</topic><topic>Dopamine</topic><topic>Dopamine - metabolism</topic><topic>Dynorphin</topic><topic>Dynorphins - biosynthesis</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hedonic response</topic><topic>Hypothalamus</topic><topic>Hypothalamus (lateral)</topic><topic>Hypothalamus - metabolism</topic><topic>Intracellular Signaling Peptides and Proteins - biosynthesis</topic><topic>Male</topic><topic>mPFC</topic><topic>Nervous system</topic><topic>Neurology</topic><topic>Neuropeptides</topic><topic>Neuropeptides - biosynthesis</topic><topic>Nucleus accumbens</topic><topic>orexin</topic><topic>Orexins</topic><topic>Prefrontal Cortex - metabolism</topic><topic>Radioimmunoassay</topic><topic>Rats</topic><topic>Rats, Long-Evans</topic><topic>Reinforcement</topic><topic>Social interactions</topic><topic>Ventral Tegmental Area - metabolism</topic><topic>Ventral tegmentum</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>VTA</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nocjar, C</creatorcontrib><creatorcontrib>Zhang, J</creatorcontrib><creatorcontrib>Feng, P</creatorcontrib><creatorcontrib>Panksepp, J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nocjar, C</au><au>Zhang, J</au><au>Feng, P</au><au>Panksepp, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The social defeat animal model of depression shows diminished levels of orexin in mesocortical regions of the dopamine system, and of dynorphin and orexin in the hypothalamus</atitle><jtitle>Neuroscience</jtitle><addtitle>Neuroscience</addtitle><date>2012-08-30</date><risdate>2012</risdate><volume>218</volume><spage>138</spage><epage>153</epage><pages>138-153</pages><issn>0306-4522</issn><eissn>1873-7544</eissn><coden>NRSCDN</coden><abstract>Highlights ► Orexin was decreased in the dopamine system in social-defeat model of depression. ► Orexin and dynorphin were both decreased in the hypothalamus in this model. ► These neuropeptide changes were seen when the model expressed sexual anhedonia. ► Anhedonia and apathy symptomology were persistently shown by the model. ► Chronic defeat crouch behavior predicted hypothalamic orexin loss in this model.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>22626650</pmid><doi>10.1016/j.neuroscience.2012.05.033</doi><tpages>16</tpages></addata></record> |
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| subjects | Anhedonia Animal models Animals Biological and medical sciences Brain Brain - metabolism Cortex (prefrontal) Depression Depression - metabolism Disease Models, Animal Dopamine Dopamine - metabolism Dynorphin Dynorphins - biosynthesis Enzyme-Linked Immunosorbent Assay Fundamental and applied biological sciences. Psychology Hedonic response Hypothalamus Hypothalamus (lateral) Hypothalamus - metabolism Intracellular Signaling Peptides and Proteins - biosynthesis Male mPFC Nervous system Neurology Neuropeptides Neuropeptides - biosynthesis Nucleus accumbens orexin Orexins Prefrontal Cortex - metabolism Radioimmunoassay Rats Rats, Long-Evans Reinforcement Social interactions Ventral Tegmental Area - metabolism Ventral tegmentum Vertebrates: nervous system and sense organs VTA |
| title | The social defeat animal model of depression shows diminished levels of orexin in mesocortical regions of the dopamine system, and of dynorphin and orexin in the hypothalamus |
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