The social defeat animal model of depression shows diminished levels of orexin in mesocortical regions of the dopamine system, and of dynorphin and orexin in the hypothalamus

Highlights ► Orexin was decreased in the dopamine system in social-defeat model of depression. ► Orexin and dynorphin were both decreased in the hypothalamus in this model. ► These neuropeptide changes were seen when the model expressed sexual anhedonia. ► Anhedonia and apathy symptomology were pers...

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Veröffentlicht in:	Neuroscience 2012-08, Vol.218, p.138-153
Hauptverfasser:	Nocjar, C, Zhang, J, Feng, P, Panksepp, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Anhedonia Animal models Animals Biological and medical sciences Brain Brain - metabolism Cortex (prefrontal) Depression Depression - metabolism Disease Models, Animal Dopamine Dopamine - metabolism Dynorphin Dynorphins - biosynthesis Enzyme-Linked Immunosorbent Assay Fundamental and applied biological sciences. Psychology Hedonic response Hypothalamus Hypothalamus (lateral) Hypothalamus - metabolism Intracellular Signaling Peptides and Proteins - biosynthesis Male mPFC Nervous system Neurology Neuropeptides Neuropeptides - biosynthesis Nucleus accumbens orexin Orexins Prefrontal Cortex - metabolism Radioimmunoassay Rats Rats, Long-Evans Reinforcement Social interactions Ventral Tegmental Area - metabolism Ventral tegmentum Vertebrates: nervous system and sense organs VTA
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Zusammenfassung:	Highlights ► Orexin was decreased in the dopamine system in social-defeat model of depression. ► Orexin and dynorphin were both decreased in the hypothalamus in this model. ► These neuropeptide changes were seen when the model expressed sexual anhedonia. ► Anhedonia and apathy symptomology were persistently shown by the model. ► Chronic defeat crouch behavior predicted hypothalamic orexin loss in this model.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2012.05.033