High-mobility group box 1 contributes to mechanical allodynia and spinal astrocytic activation in a mouse model of type 2 diabetes

Highlights ► HMGB1 is significantly increased in spinal dorsal horn of type 2 diabetic mice. ► Inhibiting HMGB1 expression significantly attenuates diabetic pain. ► Diabetes-induced astrocytic activation could be reversed by inhibiting HMGB1.

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Bibliographische Detailangaben
Veröffentlicht in:	Brain research bulletin 2012-07, Vol.88 (4), p.332-337
Hauptverfasser:	Ren, Peng-Cheng, Zhang, Yong, Zhang, Xu-Dong, An, Li-Jun, Lv, Hai-Gang, He, Jun, Gao, Chang-Jun, Sun, Xu-De
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Antibodies Astrocyte Astrocytes - metabolism Blotting, Western Chronic Pain - etiology Chronic Pain - genetics Chronic Pain - metabolism Data processing Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - metabolism Disease Models, Animal Dorsal horn Glial fibrillary acidic protein High-mobility group box 1 HMGB1 protein HMGB1 Protein - genetics HMGB1 Protein - metabolism Hyperalgesia - etiology Hyperalgesia - genetics Hyperalgesia - metabolism Immunohistochemistry Inflammation Interleukin 1 Interleukin 6 Mice Mice, Inbred C57BL Monocyte chemoattractant protein 1 Neurology Pain Pain perception Polymerase chain reaction Real-Time Polymerase Chain Reaction Spinal cord Spinal Cord - metabolism Spinal dorsal horn Tumor necrosis factor- alpha Western blotting
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Beschreibung
Zusammenfassung:	Highlights ► HMGB1 is significantly increased in spinal dorsal horn of type 2 diabetic mice. ► Inhibiting HMGB1 expression significantly attenuates diabetic pain. ► Diabetes-induced astrocytic activation could be reversed by inhibiting HMGB1.
ISSN:	0361-9230 1873-2747
DOI:	10.1016/j.brainresbull.2012.03.002