Experience-dependent expression of rat hippocampal Arc and Homer 1a after spatial learning on 8-arm and 12-arm radial mazes

Highlights ► Arc and Homer 1a expression was evaluated in rat hippocampus after maze learning. ► Co-expression of Arc and H1a is responsive to changes in spatial task demands. ► Arc and H1a expression level is in positive correlation with the behavioral performance. ► IEG expression in the hippocamp...

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Veröffentlicht in:	Neuroscience 2012-08, Vol.218, p.49-55
Hauptverfasser:	Nikbakht, N, Zarei, B, Shirani, E, Moshtaghian, J, Esmaeili, A, Habibian, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Carrier Proteins - biosynthesis Cytoskeletal Proteins - biosynthesis Fundamental and applied biological sciences. Psychology Gene expression Hippocampus Hippocampus - metabolism Homer protein Homer Scaffolding Proteins immediate early genes learning Male Maze learning Maze Learning - physiology memory Nerve Tissue Proteins - biosynthesis Nervous system Neurology Polymerase chain reaction qRT-PCR radial-arm maze Rats Rats, Wistar Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis Spatial Behavior - physiology Spatial discrimination learning spatial memory Transcriptome Vertebrates: nervous system and sense organs
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Beschreibung
Zusammenfassung:	Highlights ► Arc and Homer 1a expression was evaluated in rat hippocampus after maze learning. ► Co-expression of Arc and H1a is responsive to changes in spatial task demands. ► Arc and H1a expression level is in positive correlation with the behavioral performance. ► IEG expression in the hippocampus decreases when the spatial task is learned. ► Arc and H1a expression levels increase during memory retrieval.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2012.05.025