Ghrelin-deficient mice have fewer orexin cells and reduced cFOS expression in the mesolimbic dopamine pathway under a restricted feeding paradigm

Highlights ► cFOS induced by scheduled feeding is reduced in the VTA and accumbens of GHSR knock-out mice. ► Mice lacking ghrelin or its receptor have reduced orexin neurons in the lateral hypothalamus. ► Ghrelin may be important for the development of the orexin system.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2012-08, Vol.218, p.12-19
Hauptverfasser:	Lamont, E.W, Patterson, Z, Rodrigues, T, Vallejos, O, Blum, I.D, Abizaid, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences cFOS Data processing Dopamine Dopamine - metabolism Feeding Feeding Behavior - physiology Food Food Deprivation Fundamental and applied biological sciences. Psychology ghrelin Ghrelin - deficiency Ghrelin - metabolism Hypothalamic Area, Lateral - metabolism Hypothalamus Immunohistochemistry Intracellular Signaling Peptides and Proteins - metabolism lateral hypothalamus Locomotor activity Male mesolimbic dopamine system Mesolimbic system Mice Mice, Knockout Motivation Nervous system Neural Pathways - metabolism Neurology Neurons Neurons - metabolism Neuropeptides - metabolism Nucleus accumbens orexin Orexins Proto-Oncogene Proteins c-fos - biosynthesis Reinforcement restricted feeding Reward Stomach Transcriptome Ventral tegmentum Vertebrates: nervous system and sense organs
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights ► cFOS induced by scheduled feeding is reduced in the VTA and accumbens of GHSR knock-out mice. ► Mice lacking ghrelin or its receptor have reduced orexin neurons in the lateral hypothalamus. ► Ghrelin may be important for the development of the orexin system.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2012.05.046