The negative effects of alcohol hangover on high-anxiety phenotype rats are influenced by the glutamate receptors of the dorsal midbrain

Highlights ► LA and HA rats were tested under alcohol hangover. ► Anxiety and blood-alcohol levels were analyzed at the moment of the hangover phase. ► Glutamatergic excitatory tonus in DPAG was blocked. ► HA rats are more sensitive to the reinforcer effects of alcohol during hangover. ► These effec...

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Veröffentlicht in:	Neuroscience 2012-06, Vol.213, p.93-105
Hauptverfasser:	Ezequiel Leite, L, Nobre, M.J
Format:	Artikel
Sprache:	eng
Schlagworte:	alcohol hangover Alcoholic beverages Alcoholism Alcoholism - complications Alcoholism - metabolism alpha -Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid Animals Anxiety Anxiety - chemically induced Anxiolytics Biological and medical sciences Data processing Drinking behavior Drug abuse Emotions Esters Ethanol Ethanol - toxicity Excitatory Amino Acid Antagonists - pharmacology excitatory amino acids Fundamental and applied biological sciences. Psychology glutamate Glutamic acid receptors Glutamic acid receptors (ionotropic) Intoxication Laboratory animals Male Mesencephalon Mesencephalon - metabolism midbrain N-Methyl-D-aspartic acid receptors Nervous system Neurology Neurotransmission Operant response Periaqueductal gray area Phenotype Rats Rats, Wistar Receptors, Glutamate - metabolism Seizures Substance Withdrawal Syndrome - metabolism Vertebrates: nervous system and sense organs
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