The negative effects of alcohol hangover on high-anxiety phenotype rats are influenced by the glutamate receptors of the dorsal midbrain

The negative effects of alcohol hangover on high-anxiety phenotype rats are influenced by the glutamate receptors of the dorsal midbrain

Highlights ► LA and HA rats were tested under alcohol hangover. ► Anxiety and blood-alcohol levels were analyzed at the moment of the hangover phase. ► Glutamatergic excitatory tonus in DPAG was blocked. ► HA rats are more sensitive to the reinforcer effects of alcohol during hangover. ► These effec...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Neuroscience 2012-06, Vol.213, p.93-105
Hauptverfasser: Ezequiel Leite, L, Nobre, M.J
Format: Artikel
Sprache:eng
Schlagworte:
alcohol hangover
Alcoholic beverages
Alcoholism
Alcoholism - complications
Alcoholism - metabolism
alpha -Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid
Animals
Anxiety
Anxiety - chemically induced
Anxiolytics
Biological and medical sciences
Data processing
Drinking behavior
Drug abuse
Emotions
Esters
Ethanol
Ethanol - toxicity
Excitatory Amino Acid Antagonists - pharmacology
excitatory amino acids
Fundamental and applied biological sciences. Psychology
glutamate
Glutamic acid receptors
Glutamic acid receptors (ionotropic)
Intoxication
Laboratory animals
Male
Mesencephalon
Mesencephalon - metabolism
midbrain
N-Methyl-D-aspartic acid receptors
Nervous system
Neurology
Neurotransmission
Operant response
Periaqueductal gray area
Phenotype
Rats
Rats, Wistar
Receptors, Glutamate - metabolism
Seizures
Substance Withdrawal Syndrome - metabolism
Vertebrates: nervous system and sense organs
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Highlights ► LA and HA rats were tested under alcohol hangover. ► Anxiety and blood-alcohol levels were analyzed at the moment of the hangover phase. ► Glutamatergic excitatory tonus in DPAG was blocked. ► HA rats are more sensitive to the reinforcer effects of alcohol during hangover. ► These effects are possibly mediated by NMDA and AMPA receptors in DPAG.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2012.04.009