Sustained expression of brain-derived neurotrophic factor is required for maintenance of dendritic spines and normal behavior

Highlights ► Adult forebrain BDNF knockouts have smaller brains and many normal behaviors. ► Adult forebrain BDNF knockouts have reduced spatial learning and increased depression. ► Spine density is reduced by P84 in adult forebrain BDNF knockouts. ► Neuronal BDNF is necessary in adulthood to mainta...

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Veröffentlicht in:	Neuroscience 2012-06, Vol.212, p.1-18
Hauptverfasser:	Vigers, A.J, Amin, D.S, Talley-Farnham, T, Gorski, J.A, Xu, B, Jones, K.R
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Animals Anxiety Ataxia BDNF behavior Behavior, Animal - physiology Biological and medical sciences Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - biosynthesis Brain-Derived Neurotrophic Factor - deficiency Brain-Derived Neurotrophic Factor - genetics Cell survival Central nervous system Cerebral Cortex - growth & development Cerebral Cortex - metabolism Cortex Dendritic branching Dendritic spines Dendritic Spines - metabolism Dendritic Spines - pathology Depression Developmental Disabilities - genetics Developmental Disabilities - metabolism Developmental Disabilities - physiopathology Disease Models, Animal Eye and associated structures. Visual pathways and centers. Vision Female Forebrain Fundamental and applied biological sciences. Psychology Hippocampus Male memory Mental Disorders - genetics Mental Disorders - metabolism Mental Disorders - physiopathology Mice Mice, Knockout Mice, Transgenic Nervous system Neurology neurotrophic factor Plasticity (axonal) Plasticity (developmental) Siblings Spatial discrimination learning spatial memory Synaptic strength Vertebrates: nervous system and sense organs visual cortex
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Zusammenfassung:	Highlights ► Adult forebrain BDNF knockouts have smaller brains and many normal behaviors. ► Adult forebrain BDNF knockouts have reduced spatial learning and increased depression. ► Spine density is reduced by P84 in adult forebrain BDNF knockouts. ► Neuronal BDNF is necessary in adulthood to maintain normal spine density and behavior.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2012.03.031