Comparison of commercial molecular assays for toxigenic Clostridium difficile detection in stools: BD GeneOhm Cdiff, XPert C. difficile and illumigene C. difficile

Three commercial molecular assays were evaluated for toxigenic Clostridium difficile detection in stools. As compared to toxigenic culture, BD GeneOhm Cdiff (BD Diagnostics), XPert C. difficile (Cepheid) and illumigene C. difficile (Meridian Bioscience) demonstrated respectively a sensitivity of 95....

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Veröffentlicht in:	Journal of microbiological methods 2012-08, Vol.90 (2), p.83-85
Hauptverfasser:	Viala, Céline, Le Monnier, Alban, Maataoui, Naouale, Rousseau, Clotilde, Collignon, Anne, Poilane, Isabelle
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Toxins - metabolism Bacteriological Techniques - methods Biological and medical sciences Clostridium difficile Clostridium difficile - genetics Clostridium difficile - isolation & purification Clostridium difficile - pathogenicity Clostridium Infections - diagnosis Clostridium Infections - microbiology Diagnosis feces Feces - microbiology Fundamental and applied biological sciences. Psychology Humans Microbiology molecular biology Molecular Diagnostic Techniques - methods Molecular methods pathogen identification Reagent Kits, Diagnostic Sensitivity and Specificity
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Zusammenfassung:	Three commercial molecular assays were evaluated for toxigenic Clostridium difficile detection in stools. As compared to toxigenic culture, BD GeneOhm Cdiff (BD Diagnostics), XPert C. difficile (Cepheid) and illumigene C. difficile (Meridian Bioscience) demonstrated respectively a sensitivity of 95.5%, 97.8% and 86.7% and a specificity of 97.9%, 97.9% and 100%.
ISSN:	0167-7012 1872-8359
DOI:	10.1016/j.mimet.2012.04.017