Autophagy activation is associated with neuroprotection against apoptosis via a mitochondrial pathway in a rat model of subarachnoid hemorrhage

Highlights ► We assessed the role of autophagy in endovascular perforation SAH model. ► Autophagy has a beneficial role in early brain injury following SAH. ► This neuroprotective effect was associated with inhibition of apoptotic cell death. ► The mitochondrial pathway was involved in autophagy-mod...

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Veröffentlicht in:	Neuroscience 2012-06, Vol.213, p.144-153
Hauptverfasser:	Jing, C.-h, Wang, L, Liu, P.-p, Wu, C, Ruan, D, Chen, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - analogs & derivatives Adenine - pharmacology Animals Apoptosis Apoptosis - drug effects Apoptosis - physiology autophagy Autophagy - drug effects Autophagy - physiology Bax protein Biological and medical sciences Blotting, Western Brain injury Caspase-3 Cytochrome c Cytosol Disease Models, Animal early brain injury Edema Fundamental and applied biological sciences. Psychology In Situ Nick-End Labeling Light chains Male Medical sciences Microscopy, Confocal Microscopy, Electron, Transmission Microtubule-associated protein 1 Mitochondria Mitochondria - metabolism Mitochondria - pathology Nervous system Neurological diseases Neurology Neuroprotection Neuroprotective Agents - pharmacology Phagocytosis Rapamycin Rats Rats, Sprague-Dawley Sirolimus - pharmacology subarachnoid hemorrhage Subarachnoid Hemorrhage - physiopathology Translocation Vacuoles Vascular diseases and vascular malformations of the nervous system Vertebrates: nervous system and sense organs
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Zusammenfassung:	Highlights ► We assessed the role of autophagy in endovascular perforation SAH model. ► Autophagy has a beneficial role in early brain injury following SAH. ► This neuroprotective effect was associated with inhibition of apoptotic cell death. ► The mitochondrial pathway was involved in autophagy-modulated apoptosis after SAH.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2012.03.055