Hydrogen-rich saline protects against oxidative damage and cognitive deficits after mild traumatic brain injury

Highlights ► The study examines the effect of hydrogen-rich saline on cognitive deficits after traumatic brain injury (TBI). ► Hydrogen-rich saline can protect against oxidative damage and cognitive deficits. ► Hydrogen-rich saline may be effective for patients with cognitive deficits after TBI....

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Veröffentlicht in:	Brain research bulletin 2012-09, Vol.88 (6), p.560-565
Hauptverfasser:	Hou, Zonggang, Luo, Wei, Sun, Xuejun, Hao, Shuyu, Zhang, Ying, Xu, Feifan, Wang, Zhongcheng, Liu, Baiyun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidant Antioxidants - administration & dosage Antioxidants - therapeutic use Brain Injuries - complications Brain Injuries - drug therapy Brain-Derived Neurotrophic Factor - physiology Cognition Disorders - etiology Cognition Disorders - prevention & control Drug Evaluation, Preclinical Escape Reaction - drug effects Hippocampus Hippocampus - chemistry Hydrogen - administration & dosage Hydrogen - therapeutic use Hydrogen-rich saline Lipid Peroxidation - drug effects Malondialdehyde - analysis Maze Learning - drug effects Models, Animal Nerve Tissue Proteins - biosynthesis Nerve Tissue Proteins - genetics Neurology Neuronal Plasticity - drug effects Neuroprotection Oxidative stress Oxidative Stress - drug effects Random Allocation Rats Rats, Sprague-Dawley Sirtuin 2 - biosynthesis Sirtuin 2 - genetics Sodium Chloride - administration & dosage Traumatic brain injury
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Zusammenfassung:	Highlights ► The study examines the effect of hydrogen-rich saline on cognitive deficits after traumatic brain injury (TBI). ► Hydrogen-rich saline can protect against oxidative damage and cognitive deficits. ► Hydrogen-rich saline may be effective for patients with cognitive deficits after TBI.
ISSN:	0361-9230 1873-2747
DOI:	10.1016/j.brainresbull.2012.06.006