Anti-nociceptive effects of Tanshinone IIA (TIIA) in a rat model of complete Freund's adjuvant (CFA)-induced inflammatory pain

Highlights ► TIIA has anti-nociceptive effects in a rat model of CFA-induced inflammatory pain. ► ERK and the cytokines can be inhibited by TIIA in the inflammatory pain model. ► TRPV1 in DRG can be reduced after TIIA administration in inflammatory pain. ► TIIA may be a potential anti-inflammatory a...

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Veröffentlicht in:	Brain research bulletin 2012-09, Vol.88 (6), p.581-588
Hauptverfasser:	Sun, Shukai, Yin, Yue, Yin, Xin, Cao, Fale, Luo, Daoshu, Zhang, Ting, Li, Yunqing, Ni, Longxing
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics, Non-Narcotic - pharmacology Analgesics, Non-Narcotic - therapeutic use Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Arthritis, Experimental - drug therapy Arthritis, Experimental - etiology CFA Cytokines - biosynthesis Cytokines - genetics Diterpenes, Abietane - pharmacology Diterpenes, Abietane - therapeutic use Drug Evaluation, Preclinical Drugs, Chinese Herbal - pharmacology Drugs, Chinese Herbal - therapeutic use ERK Freund's Adjuvant - toxicity Ganglia, Spinal - chemistry Ganglia, Spinal - drug effects Gene Expression Regulation - drug effects Hot Temperature - adverse effects Hyperalgesia - drug therapy Hyperalgesia - etiology Inflammatory pain Lumbosacral Region Male MAP Kinase Signaling System - drug effects Neurology NF-kappa B - analysis Random Allocation Rats Rats, Sprague-Dawley RNA, Messenger - biosynthesis RNA, Messenger - genetics Single-Blind Method Stress, Mechanical Tanshinone IIA TRPV Cation Channels - analysis TRPV Cation Channels - biosynthesis TRPV Cation Channels - genetics TRPV1
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Zusammenfassung:	Highlights ► TIIA has anti-nociceptive effects in a rat model of CFA-induced inflammatory pain. ► ERK and the cytokines can be inhibited by TIIA in the inflammatory pain model. ► TRPV1 in DRG can be reduced after TIIA administration in inflammatory pain. ► TIIA may be a potential anti-inflammatory and anti-nociceptive drug in clinic.
ISSN:	0361-9230 1873-2747
DOI:	10.1016/j.brainresbull.2012.06.002