A benchmark study on 883 nasopharyngeal cancer patients treated in two Italian Centres from 1977 to 2000. Part I: evolving technical choices and survival

Purpose The authors sought to define treatment results according to the different accrual periods and clinical-therapeutic features in a large series of nasopharyngeal cancer (NPC) patients treated in two Italian centres over more than two decades. Materials and methods A total of 883 patients conse...

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Veröffentlicht in:Radiologia medica 2012-06, Vol.117 (4), p.690-714
Hauptverfasser: Tonoli, S., Magrini, S. M., Costa, L., Paiar, F., Simontacchi, G., Scotti, V., Pasinetti, N., Barca, R., Barbieri, D., De Stefani, A., Cellai, E., Buglione, M., Biti, G.
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Sprache:eng
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Zusammenfassung:Purpose The authors sought to define treatment results according to the different accrual periods and clinical-therapeutic features in a large series of nasopharyngeal cancer (NPC) patients treated in two Italian centres over more than two decades. Materials and methods A total of 883 patients consecutively treated with radiotherapy between 1977 and 2000 at the Florence (FLO) and Brescia (IRA) Radiation Oncology centres were studied. Five-year overall (OS) and disease-specific (DSS) actuarial survival rates in the different pathological, clinical and therapeutic subgroups were calculated, along with the actuarial local-regional control (LRC) probability. Results At univariate analysis, survival and local control rates were significantly better in the more recent accrual periods and in the more favourable disease presentations; treatment-related parameters mainly affect LRC. At multivariate analysis, patient- and disease-related factors had a more evident prognostic effect than did therapeutic factors, although dose to the nasopharynx and treatment technique had a marginally significant impact on DSS and OS. Conclusions Results of this benchmark study may be useful for understanding the development of new radio-therapy techniques for NPC, such as three-dimensional conformal radiotherapy (3D-CRT) and particularly intensity-modulated radiotherapy (IMRT).
ISSN:0033-8362
1826-6983
DOI:10.1007/s11547-011-0755-9