Behavioral Effects of Original Tetrapeptide, an Analog of N-Terminal Nociceptin Fragment

The study examined the effect of an analog to N-terminal nociceptin fragment AcOH × Phe-Gly-Gly-Phe-NH 2 on the behavior of albino rats. This tetrapeptide (5 μg/kg intraperitoneally) signifi cantly enhanced motor and exploratory activity in mature rats and in 42-day pups and produced opposite effect...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2012-06, Vol.153 (2), p.177-181
Hauptverfasser:	Ivanova, E. A., Sarycheva, N. Yu, Dubynin, V. A., Malyshev, A. V., Kalikhevich, V. N., Ardemasova, Z. A., Kamensky, A. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Animals Behavior, Animal - drug effects Biomedical and Life Sciences Biomedicine Cell Biology Exploratory Behavior - drug effects Female Glycine Internal Medicine Laboratory Medicine Male Motor Activity - drug effects Nervous System - drug effects Nervous System - growth & development Nociceptin Opioid Peptides - chemistry Opioid Peptides - pharmacology Pathology Peptide Fragments - chemistry Peptide Fragments - pharmacology Rats Receptors, Opioid - agonists Receptors, Opioid - chemistry Receptors, Opioid - metabolism Structure-Activity Relationship
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Beschreibung
Zusammenfassung:	The study examined the effect of an analog to N-terminal nociceptin fragment AcOH × Phe-Gly-Gly-Phe-NH 2 on the behavior of albino rats. This tetrapeptide (5 μg/kg intraperitoneally) signifi cantly enhanced motor and exploratory activity in mature rats and in 42-day pups and produced opposite effects in 21-day rat pups, which attests to the complex dynamics of maturation of nervous structures involved in the realization of nociceptin action.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-012-1670-3