Isolation of Antitrypanosomal Compounds from Vitis repens, a Medicinal Plant of Myanmar

Isolation of Antitrypanosomal Compounds from Vitis repens, a Medicinal Plant of Myanmar

Bioactivity-guided fractionation of an ethanolic extract of Vitis repens led to the isolation of resveratrol (1), 11-O-acetyl bergenin (2), and stigmast-4-en-3-one (3). The compounds were examined for their in vitro antitrypanosomal activities against trypomastigotes of Trypanosoma evansi. Resveratr...

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Veröffentlicht in:Natural product communications 2012-05, Vol.7 (5), p.609-610
Hauptverfasser: Nyunt, Khine Swe, Elkhateeb, Ahmed, Tosa, Yusuke, Nabata, Kensuke, Katakura, Ken, Matsuura, Hideyuki
Format: Artikel
Sprache:eng
Schlagworte:
Myanmar
Plant Extracts - analysis
Plants, Medicinal - chemistry
Trypanocidal Agents - isolation & purification
Trypanocidal Agents - pharmacology
Trypanosoma - drug effects
Vitis - chemistry
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Zusammenfassung:Bioactivity-guided fractionation of an ethanolic extract of Vitis repens led to the isolation of resveratrol (1), 11-O-acetyl bergenin (2), and stigmast-4-en-3-one (3). The compounds were examined for their in vitro antitrypanosomal activities against trypomastigotes of Trypanosoma evansi. Resveratrol showed antitrypanosomal activity with an IC50 value of 0.13 μM, whereas 11-O-acetyl bergenin and stigmast-4-en-3-one exhibited IC50 values of 0.17 and 0.15 μM, respectively.
ISSN:1934-578X
1555-9475
DOI:10.1177/1934578X1200700516