Effects of Fullerene C60 Nanocomposites on Human Platelet Aggregation

The effects of fullerene C 60 nanocomposites on human platelet aggregation induced by ADP, ristocetin, and collagen were studied. The nanocomposite containing fullerene C 60 in polyvinyl pyrrolidone solution did not change platelet aggregation, while fullerene C 60 in crown ether and Twin-80 solutio...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2012-03, Vol.152 (5), p.624-626
Hauptverfasser:	Vaschenko, V. I., Samonin, V. V., Popov, V. A., Antonenkova, E. V., Nikonova, V. J., Vilyaninov, V. N., Podvjaznikov, M. L., Kidalov, V. N., Titulova, T. B., Vaschenko, T. N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - pharmacology Biomedical and Life Sciences Biomedicine Blood Platelets - drug effects Cell Biology Cells, Cultured Collagen - pharmacology Crown Ethers - chemistry Fullerenes - chemistry Fullerenes - pharmacology Humans Internal Medicine Laboratory Medicine Nanocomposites - chemistry Pathology Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - pharmacology Povidone - chemistry Ristocetin - pharmacology Surface-Active Agents - chemistry
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Zusammenfassung:	The effects of fullerene C 60 nanocomposites on human platelet aggregation induced by ADP, ristocetin, and collagen were studied. The nanocomposite containing fullerene C 60 in polyvinyl pyrrolidone solution did not change platelet aggregation, while fullerene C 60 in crown ether and Twin-80 solutions inhibited ADP-induced platelet aggregation by 20 and 30%, respectively.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-012-1592-0