Importance of infectious bovine reproductive diseases: an example from Ghana
The minimum sample size was calculated with a power of 0.8 and using the lowest assumed prevalence of any of the diseases of interest (approximately 10 per cent as predicted from the literature); that is, approximately 116 animals (Dean AG, Sullivan KM, Soe MM. OpenEpi: Open Source Epidemiologic Sta...
Gespeichert in:
Veröffentlicht in: | Veterinary record 2012-07, Vol.171 (2), p.47-47 |
---|---|
Hauptverfasser: | , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 47 |
---|---|
container_issue | 2 |
container_start_page | 47 |
container_title | Veterinary record |
container_volume | 171 |
creator | Adu-Addai, B. Koney, E. B. Addo, P. Kaneene, J. Mackenzie, C. Agnew, D. W. |
description | The minimum sample size was calculated with a power of 0.8 and using the lowest assumed prevalence of any of the diseases of interest (approximately 10 per cent as predicted from the literature); that is, approximately 116 animals (Dean AG, Sullivan KM, Soe MM. OpenEpi: Open Source Epidemiologic Statistics for Public Health, Version 2.3.1. www.OpenEpi.com , updated June 23, 2011, accessed April 12, 2012). ELISA seropositivity (% of animals) - IBR BVD BHV-4 Test result Male Female Total Male Female Total Male Female Total Negative 37.0 30.1 31.0 100 84.9 87.0 89.5 78.1 79.4 Positive 63.0 69.9 69.0 0.0 15.1 13.0 10.5 21.9 20.6 - ELISA Seropositivity (% of animals) - C burnetii B abortus N caninum Test result Male Female Total Male Female Total Male Female Total Negative 83.4 74.0 75.0 100 100 100 88.9 94.6 93.9 Positive 5.6 19.2 17.7 0.0 0.0 0.0 11.1 5.4 6.1 Suspect * 11.0 6.8 7.3 0.0 0.0 0.0 0.0 0.0 0.0 'Suspect' refers to samples that were intermediate in reactivity and could not be accurately interpreted The haemolytic assay indicated that 47.6 per cent of cattle tested were positive for T foetus; however, no T foetus organisms were isolated via culture from any animals in the herd ( Table 3 ). - |
doi_str_mv | 10.1136/vr.100789 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1026863278</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4015342571</sourcerecordid><originalsourceid>FETCH-LOGICAL-b3852-1951d226e3f567459113d215c986e91d04d212ec6f5d74690bea545cecfd1883</originalsourceid><addsrcrecordid>eNp9kF9LwzAUxYMobk4f_AIS0Ad92Exum6TxTcemg4Egw9eStrfY0T8zWaf79mZ0-iDoU5LL75x7cgg552zEeSBvN3bEGVORPiB9YCEMlVTskPTZ7h5qxnrkxLklY6BFAMekB6CYZIHuk_msWjV2beoUaZPTos4xXRdN62jSbIoaqcWVbbLWDzdIs8KhcejuqKkpfppqVSLNbVPRxzdTm1NylJvS4dn-HJDFdLIYPw3nz4-z8f18mASRgCHXgmcAEoNcSBUK7T-RARepjiRqnrHQvwBTmYtMhVKzBI0IRYppnvEoCgbkurP1yd5bdOu4KlyKZWlq9MljzkBGMgC1Qy9_ocumtbUPF3OltBBSgPTUTUeltnHOYh6vbFEZu_VW8a7heGPjrmHPXuwd26TC7If8rtQD0AEfRYnbv53i18ni5WEKgRbgRVedKKmW_yz_AmxDj1U</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1779556526</pqid></control><display><type>article</type><title>Importance of infectious bovine reproductive diseases: an example from Ghana</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Adu-Addai, B. ; Koney, E. B. ; Addo, P. ; Kaneene, J. ; Mackenzie, C. ; Agnew, D. W.</creator><creatorcontrib>Adu-Addai, B. ; Koney, E. B. ; Addo, P. ; Kaneene, J. ; Mackenzie, C. ; Agnew, D. W.</creatorcontrib><description>The minimum sample size was calculated with a power of 0.8 and using the lowest assumed prevalence of any of the diseases of interest (approximately 10 per cent as predicted from the literature); that is, approximately 116 animals (Dean AG, Sullivan KM, Soe MM. OpenEpi: Open Source Epidemiologic Statistics for Public Health, Version 2.3.1. www.OpenEpi.com , updated June 23, 2011, accessed April 12, 2012). ELISA seropositivity (% of animals) - IBR BVD BHV-4 Test result Male Female Total Male Female Total Male Female Total Negative 37.0 30.1 31.0 100 84.9 87.0 89.5 78.1 79.4 Positive 63.0 69.9 69.0 0.0 15.1 13.0 10.5 21.9 20.6 - ELISA Seropositivity (% of animals) - C burnetii B abortus N caninum Test result Male Female Total Male Female Total Male Female Total Negative 83.4 74.0 75.0 100 100 100 88.9 94.6 93.9 Positive 5.6 19.2 17.7 0.0 0.0 0.0 11.1 5.4 6.1 Suspect * 11.0 6.8 7.3 0.0 0.0 0.0 0.0 0.0 0.0 'Suspect' refers to samples that were intermediate in reactivity and could not be accurately interpreted The haemolytic assay indicated that 47.6 per cent of cattle tested were positive for T foetus; however, no T foetus organisms were isolated via culture from any animals in the herd ( Table 3 ). -</description><identifier>ISSN: 0042-4900</identifier><identifier>EISSN: 2042-7670</identifier><identifier>DOI: 10.1136/vr.100789</identifier><identifier>PMID: 22706039</identifier><language>eng</language><publisher>England: BMJ Publishing Group Limited</publisher><subject>Abortion, Veterinary ; Age ; Animals ; Antibodies, Bacterial - blood ; Antibodies, Protozoan - blood ; Antibodies, Viral - blood ; Bovine Virus Diarrhea-Mucosal Disease - epidemiology ; Bovine Virus Diarrhea-Mucosal Disease - physiopathology ; Brucellosis ; Cattle ; Cattle Diseases - epidemiology ; Cattle Diseases - physiopathology ; Causality ; Diarrhea Viruses, Bovine Viral - immunology ; Female ; Females ; Ghana ; Herpesviridae - immunology ; Herpesviridae Infections - epidemiology ; Herpesviridae Infections - physiopathology ; Herpesviridae Infections - veterinary ; Herpesvirus 1, Bovine - immunology ; Immunoglobulins ; Infection - epidemiology ; Infection - physiopathology ; Infection - veterinary ; Infectious Bovine Rhinotracheitis - epidemiology ; Infectious Bovine Rhinotracheitis - physiopathology ; Infertility ; Infertility, Female - veterinary ; Organisms ; Pathogens ; Pregnancy ; Pregnancy Complications, Infectious - epidemiology ; Pregnancy Complications, Infectious - veterinary ; Pregnancy Complications, Parasitic - epidemiology ; Pregnancy Complications, Parasitic - veterinary ; Protozoan Infections, Animal - epidemiology ; Protozoan Infections, Animal - physiopathology ; Uterine Diseases - veterinary</subject><ispartof>Veterinary record, 2012-07, Vol.171 (2), p.47-47</ispartof><rights>British Veterinary Association</rights><rights>British Veterinary Association 2012</rights><rights>Copyright: 2012 British Veterinary Association</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b3852-1951d226e3f567459113d215c986e91d04d212ec6f5d74690bea545cecfd1883</citedby><cites>FETCH-LOGICAL-b3852-1951d226e3f567459113d215c986e91d04d212ec6f5d74690bea545cecfd1883</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1136%2Fvr.100789$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1136%2Fvr.100789$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22706039$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Adu-Addai, B.</creatorcontrib><creatorcontrib>Koney, E. B.</creatorcontrib><creatorcontrib>Addo, P.</creatorcontrib><creatorcontrib>Kaneene, J.</creatorcontrib><creatorcontrib>Mackenzie, C.</creatorcontrib><creatorcontrib>Agnew, D. W.</creatorcontrib><title>Importance of infectious bovine reproductive diseases: an example from Ghana</title><title>Veterinary record</title><addtitle>Vet Rec</addtitle><description>The minimum sample size was calculated with a power of 0.8 and using the lowest assumed prevalence of any of the diseases of interest (approximately 10 per cent as predicted from the literature); that is, approximately 116 animals (Dean AG, Sullivan KM, Soe MM. OpenEpi: Open Source Epidemiologic Statistics for Public Health, Version 2.3.1. www.OpenEpi.com , updated June 23, 2011, accessed April 12, 2012). ELISA seropositivity (% of animals) - IBR BVD BHV-4 Test result Male Female Total Male Female Total Male Female Total Negative 37.0 30.1 31.0 100 84.9 87.0 89.5 78.1 79.4 Positive 63.0 69.9 69.0 0.0 15.1 13.0 10.5 21.9 20.6 - ELISA Seropositivity (% of animals) - C burnetii B abortus N caninum Test result Male Female Total Male Female Total Male Female Total Negative 83.4 74.0 75.0 100 100 100 88.9 94.6 93.9 Positive 5.6 19.2 17.7 0.0 0.0 0.0 11.1 5.4 6.1 Suspect * 11.0 6.8 7.3 0.0 0.0 0.0 0.0 0.0 0.0 'Suspect' refers to samples that were intermediate in reactivity and could not be accurately interpreted The haemolytic assay indicated that 47.6 per cent of cattle tested were positive for T foetus; however, no T foetus organisms were isolated via culture from any animals in the herd ( Table 3 ). -</description><subject>Abortion, Veterinary</subject><subject>Age</subject><subject>Animals</subject><subject>Antibodies, Bacterial - blood</subject><subject>Antibodies, Protozoan - blood</subject><subject>Antibodies, Viral - blood</subject><subject>Bovine Virus Diarrhea-Mucosal Disease - epidemiology</subject><subject>Bovine Virus Diarrhea-Mucosal Disease - physiopathology</subject><subject>Brucellosis</subject><subject>Cattle</subject><subject>Cattle Diseases - epidemiology</subject><subject>Cattle Diseases - physiopathology</subject><subject>Causality</subject><subject>Diarrhea Viruses, Bovine Viral - immunology</subject><subject>Female</subject><subject>Females</subject><subject>Ghana</subject><subject>Herpesviridae - immunology</subject><subject>Herpesviridae Infections - epidemiology</subject><subject>Herpesviridae Infections - physiopathology</subject><subject>Herpesviridae Infections - veterinary</subject><subject>Herpesvirus 1, Bovine - immunology</subject><subject>Immunoglobulins</subject><subject>Infection - epidemiology</subject><subject>Infection - physiopathology</subject><subject>Infection - veterinary</subject><subject>Infectious Bovine Rhinotracheitis - epidemiology</subject><subject>Infectious Bovine Rhinotracheitis - physiopathology</subject><subject>Infertility</subject><subject>Infertility, Female - veterinary</subject><subject>Organisms</subject><subject>Pathogens</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Infectious - epidemiology</subject><subject>Pregnancy Complications, Infectious - veterinary</subject><subject>Pregnancy Complications, Parasitic - epidemiology</subject><subject>Pregnancy Complications, Parasitic - veterinary</subject><subject>Protozoan Infections, Animal - epidemiology</subject><subject>Protozoan Infections, Animal - physiopathology</subject><subject>Uterine Diseases - veterinary</subject><issn>0042-4900</issn><issn>2042-7670</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kF9LwzAUxYMobk4f_AIS0Ad92Exum6TxTcemg4Egw9eStrfY0T8zWaf79mZ0-iDoU5LL75x7cgg552zEeSBvN3bEGVORPiB9YCEMlVTskPTZ7h5qxnrkxLklY6BFAMekB6CYZIHuk_msWjV2beoUaZPTos4xXRdN62jSbIoaqcWVbbLWDzdIs8KhcejuqKkpfppqVSLNbVPRxzdTm1NylJvS4dn-HJDFdLIYPw3nz4-z8f18mASRgCHXgmcAEoNcSBUK7T-RARepjiRqnrHQvwBTmYtMhVKzBI0IRYppnvEoCgbkurP1yd5bdOu4KlyKZWlq9MljzkBGMgC1Qy9_ocumtbUPF3OltBBSgPTUTUeltnHOYh6vbFEZu_VW8a7heGPjrmHPXuwd26TC7If8rtQD0AEfRYnbv53i18ni5WEKgRbgRVedKKmW_yz_AmxDj1U</recordid><startdate>20120714</startdate><enddate>20120714</enddate><creator>Adu-Addai, B.</creator><creator>Koney, E. B.</creator><creator>Addo, P.</creator><creator>Kaneene, J.</creator><creator>Mackenzie, C.</creator><creator>Agnew, D. W.</creator><general>BMJ Publishing Group Limited</general><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20120714</creationdate><title>Importance of infectious bovine reproductive diseases: an example from Ghana</title><author>Adu-Addai, B. ; Koney, E. B. ; Addo, P. ; Kaneene, J. ; Mackenzie, C. ; Agnew, D. W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b3852-1951d226e3f567459113d215c986e91d04d212ec6f5d74690bea545cecfd1883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Abortion, Veterinary</topic><topic>Age</topic><topic>Animals</topic><topic>Antibodies, Bacterial - blood</topic><topic>Antibodies, Protozoan - blood</topic><topic>Antibodies, Viral - blood</topic><topic>Bovine Virus Diarrhea-Mucosal Disease - epidemiology</topic><topic>Bovine Virus Diarrhea-Mucosal Disease - physiopathology</topic><topic>Brucellosis</topic><topic>Cattle</topic><topic>Cattle Diseases - epidemiology</topic><topic>Cattle Diseases - physiopathology</topic><topic>Causality</topic><topic>Diarrhea Viruses, Bovine Viral - immunology</topic><topic>Female</topic><topic>Females</topic><topic>Ghana</topic><topic>Herpesviridae - immunology</topic><topic>Herpesviridae Infections - epidemiology</topic><topic>Herpesviridae Infections - physiopathology</topic><topic>Herpesviridae Infections - veterinary</topic><topic>Herpesvirus 1, Bovine - immunology</topic><topic>Immunoglobulins</topic><topic>Infection - epidemiology</topic><topic>Infection - physiopathology</topic><topic>Infection - veterinary</topic><topic>Infectious Bovine Rhinotracheitis - epidemiology</topic><topic>Infectious Bovine Rhinotracheitis - physiopathology</topic><topic>Infertility</topic><topic>Infertility, Female - veterinary</topic><topic>Organisms</topic><topic>Pathogens</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Infectious - epidemiology</topic><topic>Pregnancy Complications, Infectious - veterinary</topic><topic>Pregnancy Complications, Parasitic - epidemiology</topic><topic>Pregnancy Complications, Parasitic - veterinary</topic><topic>Protozoan Infections, Animal - epidemiology</topic><topic>Protozoan Infections, Animal - physiopathology</topic><topic>Uterine Diseases - veterinary</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Adu-Addai, B.</creatorcontrib><creatorcontrib>Koney, E. B.</creatorcontrib><creatorcontrib>Addo, P.</creatorcontrib><creatorcontrib>Kaneene, J.</creatorcontrib><creatorcontrib>Mackenzie, C.</creatorcontrib><creatorcontrib>Agnew, D. W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Proquest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary record</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Adu-Addai, B.</au><au>Koney, E. B.</au><au>Addo, P.</au><au>Kaneene, J.</au><au>Mackenzie, C.</au><au>Agnew, D. W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Importance of infectious bovine reproductive diseases: an example from Ghana</atitle><jtitle>Veterinary record</jtitle><addtitle>Vet Rec</addtitle><date>2012-07-14</date><risdate>2012</risdate><volume>171</volume><issue>2</issue><spage>47</spage><epage>47</epage><pages>47-47</pages><issn>0042-4900</issn><eissn>2042-7670</eissn><abstract>The minimum sample size was calculated with a power of 0.8 and using the lowest assumed prevalence of any of the diseases of interest (approximately 10 per cent as predicted from the literature); that is, approximately 116 animals (Dean AG, Sullivan KM, Soe MM. OpenEpi: Open Source Epidemiologic Statistics for Public Health, Version 2.3.1. www.OpenEpi.com , updated June 23, 2011, accessed April 12, 2012). ELISA seropositivity (% of animals) - IBR BVD BHV-4 Test result Male Female Total Male Female Total Male Female Total Negative 37.0 30.1 31.0 100 84.9 87.0 89.5 78.1 79.4 Positive 63.0 69.9 69.0 0.0 15.1 13.0 10.5 21.9 20.6 - ELISA Seropositivity (% of animals) - C burnetii B abortus N caninum Test result Male Female Total Male Female Total Male Female Total Negative 83.4 74.0 75.0 100 100 100 88.9 94.6 93.9 Positive 5.6 19.2 17.7 0.0 0.0 0.0 11.1 5.4 6.1 Suspect * 11.0 6.8 7.3 0.0 0.0 0.0 0.0 0.0 0.0 'Suspect' refers to samples that were intermediate in reactivity and could not be accurately interpreted The haemolytic assay indicated that 47.6 per cent of cattle tested were positive for T foetus; however, no T foetus organisms were isolated via culture from any animals in the herd ( Table 3 ). -</abstract><cop>England</cop><pub>BMJ Publishing Group Limited</pub><pmid>22706039</pmid><doi>10.1136/vr.100789</doi><tpages>1</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0042-4900 |
ispartof | Veterinary record, 2012-07, Vol.171 (2), p.47-47 |
issn | 0042-4900 2042-7670 |
language | eng |
recordid | cdi_proquest_miscellaneous_1026863278 |
source | MEDLINE; Wiley Online Library All Journals |
subjects | Abortion, Veterinary Age Animals Antibodies, Bacterial - blood Antibodies, Protozoan - blood Antibodies, Viral - blood Bovine Virus Diarrhea-Mucosal Disease - epidemiology Bovine Virus Diarrhea-Mucosal Disease - physiopathology Brucellosis Cattle Cattle Diseases - epidemiology Cattle Diseases - physiopathology Causality Diarrhea Viruses, Bovine Viral - immunology Female Females Ghana Herpesviridae - immunology Herpesviridae Infections - epidemiology Herpesviridae Infections - physiopathology Herpesviridae Infections - veterinary Herpesvirus 1, Bovine - immunology Immunoglobulins Infection - epidemiology Infection - physiopathology Infection - veterinary Infectious Bovine Rhinotracheitis - epidemiology Infectious Bovine Rhinotracheitis - physiopathology Infertility Infertility, Female - veterinary Organisms Pathogens Pregnancy Pregnancy Complications, Infectious - epidemiology Pregnancy Complications, Infectious - veterinary Pregnancy Complications, Parasitic - epidemiology Pregnancy Complications, Parasitic - veterinary Protozoan Infections, Animal - epidemiology Protozoan Infections, Animal - physiopathology Uterine Diseases - veterinary |
title | Importance of infectious bovine reproductive diseases: an example from Ghana |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T06%3A33%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Importance%20of%20infectious%20bovine%20reproductive%20diseases:%20an%20example%20from%20Ghana&rft.jtitle=Veterinary%20record&rft.au=Adu-Addai,%20B.&rft.date=2012-07-14&rft.volume=171&rft.issue=2&rft.spage=47&rft.epage=47&rft.pages=47-47&rft.issn=0042-4900&rft.eissn=2042-7670&rft_id=info:doi/10.1136/vr.100789&rft_dat=%3Cproquest_cross%3E4015342571%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1779556526&rft_id=info:pmid/22706039&rfr_iscdi=true |