Cytotoxic Prodigiosin Family Pigments from Pseudoalteromonas sp. 1020R Isolated from the Pacific Coast of Japan
Pseudoalteromonas sp. 1020R, isolated from the Pacific coast of Japan, produces prodigiosin family pigments. Structural analysis indicated that these are prodigiosin (2-methyl-3-pentyl-prodiginine) and three other prodigiosin congeners which differ only in the lengths of the alkyl side chains. These...
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| Veröffentlicht in: | Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2012, Vol.76 (6), p.1229-1232 |
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| container_title | Bioscience, biotechnology, and biochemistry |
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| creator | WANG, Yi NAKAJIMA, Aya HOSOKAWA, Kakushi SOLIEV, Azamjon B. OSAKA, Issey ARAKAWA, Ryuichi ENOMOTO, Keiichi |
| description | Pseudoalteromonas sp. 1020R, isolated from the Pacific coast of Japan, produces prodigiosin family pigments. Structural analysis indicated that these are prodigiosin (2-methyl-3-pentyl-prodiginine) and three other prodigiosin congeners which differ only in the lengths of the alkyl side chains. These compounds exhibited different extents of cytotoxicity against U937 leukemia cells, and cell death was accompanied by typical features of apoptosis. |
| doi_str_mv | 10.1271/bbb.110984 |
| format | Article |
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Structural analysis indicated that these are prodigiosin (2-methyl-3-pentyl-prodiginine) and three other prodigiosin congeners which differ only in the lengths of the alkyl side chains. These compounds exhibited different extents of cytotoxicity against U937 leukemia cells, and cell death was accompanied by typical features of apoptosis.</description><identifier>ISSN: 0916-8451</identifier><identifier>EISSN: 1347-6947</identifier><identifier>DOI: 10.1271/bbb.110984</identifier><identifier>PMID: 22790952</identifier><language>eng</language><publisher>Tokyo: Japan Society for Bioscience, Biotechnology, and Agrochemistry</publisher><subject>Antineoplastic Agents - chemistry ; Antineoplastic Agents - isolation & purification ; Antineoplastic Agents - pharmacology ; apoptosis ; Apoptosis - drug effects ; Aquatic Organisms - chemistry ; Biochemistry ; Biological and medical sciences ; Biotechnology ; Caspase 3 - metabolism ; Cell death ; Coastal environments ; Congeners ; cytotoxicity ; DNA Fragmentation - drug effects ; Fundamental and applied biological sciences. Psychology ; Humans ; Japan ; Leukemias ; Magnetic Resonance Spectroscopy ; Pigments ; Pigments, Biological - chemistry ; Pigments, Biological - isolation & purification ; Pigments, Biological - pharmacology ; prodigiosin ; Prodigiosin - analogs & derivatives ; Prodigiosin - isolation & purification ; Prodigiosin - pharmacology ; Pseudoalteromonas ; Pseudoalteromonas - chemistry ; Spectrometry, Mass, Electrospray Ionization ; Structural analysis ; U937 Cells</subject><ispartof>Bioscience, biotechnology, and biochemistry, 2012, Vol.76 (6), p.1229-1232</ispartof><rights>2012 by Japan Society for Bioscience, Biotechnology, and Agrochemistry 2012</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c687t-fcbc3acbebf050f818f6ccef86c070879bc5d23a04639e82eea4feca032bf8d43</citedby><cites>FETCH-LOGICAL-c687t-fcbc3acbebf050f818f6ccef86c070879bc5d23a04639e82eea4feca032bf8d43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4022,27922,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26329497$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22790952$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>WANG, Yi</creatorcontrib><creatorcontrib>NAKAJIMA, Aya</creatorcontrib><creatorcontrib>HOSOKAWA, Kakushi</creatorcontrib><creatorcontrib>SOLIEV, Azamjon B.</creatorcontrib><creatorcontrib>OSAKA, Issey</creatorcontrib><creatorcontrib>ARAKAWA, Ryuichi</creatorcontrib><creatorcontrib>ENOMOTO, Keiichi</creatorcontrib><title>Cytotoxic Prodigiosin Family Pigments from Pseudoalteromonas sp. 1020R Isolated from the Pacific Coast of Japan</title><title>Bioscience, biotechnology, and biochemistry</title><addtitle>Biosci Biotechnol Biochem</addtitle><description>Pseudoalteromonas sp. 1020R, isolated from the Pacific coast of Japan, produces prodigiosin family pigments. Structural analysis indicated that these are prodigiosin (2-methyl-3-pentyl-prodiginine) and three other prodigiosin congeners which differ only in the lengths of the alkyl side chains. These compounds exhibited different extents of cytotoxicity against U937 leukemia cells, and cell death was accompanied by typical features of apoptosis.</description><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - isolation & purification</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Aquatic Organisms - chemistry</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Biotechnology</subject><subject>Caspase 3 - metabolism</subject><subject>Cell death</subject><subject>Coastal environments</subject><subject>Congeners</subject><subject>cytotoxicity</subject><subject>DNA Fragmentation - drug effects</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Japan</subject><subject>Leukemias</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Pigments</subject><subject>Pigments, Biological - chemistry</subject><subject>Pigments, Biological - isolation & purification</subject><subject>Pigments, Biological - pharmacology</subject><subject>prodigiosin</subject><subject>Prodigiosin - analogs & derivatives</subject><subject>Prodigiosin - isolation & purification</subject><subject>Prodigiosin - pharmacology</subject><subject>Pseudoalteromonas</subject><subject>Pseudoalteromonas - chemistry</subject><subject>Spectrometry, Mass, Electrospray Ionization</subject><subject>Structural analysis</subject><subject>U937 Cells</subject><issn>0916-8451</issn><issn>1347-6947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0V2L1DAUBuAgijuu3vgDJCCCCB3z2SSXMri6suAgel1O02TN0jZjkqLz7412VkGEvQoJT96c8CL0lJItZYq-7vt-SykxWtxDG8qFaloj1H20IYa2jRaSnqFHOd8QUg8kfYjOGFOGGMk2KO6OJZb4I1i8T3EI1yHmMOMLmMJ4xPtwPbm5ZOxTnPA-u2WIMBZXd3GGjPNhiylh5BO-zHGE4oZVlq8O78EGX2N3EXLB0eMPcID5MXrgYczuyWk9R18u3n7evW-uPr673L25amyrVWm87S0H27veE0m8ptq31jqvW0sU0cr0Vg6MAxEtN04z50B4Z4Fw1ns9CH6OXq65hxS_LS6XbgrZunGE2cUld7RVlEuuGb-bUsoZY1rKuylhwnBlJK30-T_0Ji5prn_uqBBGS0GNqurVqmyKOSfnu0MKE6Rjjep-ldvVcru13IqfnSKXfnLDH3rbZgUvTgCyhdEnmG3If13LmRG_X5WrC7OPaYLvMY1DV-A4xnR7if9ngJ8-Ur22</recordid><startdate>2012</startdate><enddate>2012</enddate><creator>WANG, Yi</creator><creator>NAKAJIMA, Aya</creator><creator>HOSOKAWA, Kakushi</creator><creator>SOLIEV, Azamjon B.</creator><creator>OSAKA, Issey</creator><creator>ARAKAWA, Ryuichi</creator><creator>ENOMOTO, Keiichi</creator><general>Japan Society for Bioscience, Biotechnology, and Agrochemistry</general><general>Japan Society for Bioscience Biotechnology and Agrochemistry</general><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QL</scope><scope>7QO</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7TB</scope><scope>7U5</scope><scope>L7M</scope></search><sort><creationdate>2012</creationdate><title>Cytotoxic Prodigiosin Family Pigments from Pseudoalteromonas sp. 1020R Isolated from the Pacific Coast of Japan</title><author>WANG, Yi ; NAKAJIMA, Aya ; HOSOKAWA, Kakushi ; SOLIEV, Azamjon B. ; OSAKA, Issey ; ARAKAWA, Ryuichi ; ENOMOTO, Keiichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c687t-fcbc3acbebf050f818f6ccef86c070879bc5d23a04639e82eea4feca032bf8d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - isolation & purification</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Aquatic Organisms - chemistry</topic><topic>Biochemistry</topic><topic>Biological and medical sciences</topic><topic>Biotechnology</topic><topic>Caspase 3 - metabolism</topic><topic>Cell death</topic><topic>Coastal environments</topic><topic>Congeners</topic><topic>cytotoxicity</topic><topic>DNA Fragmentation - drug effects</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Japan</topic><topic>Leukemias</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Pigments</topic><topic>Pigments, Biological - chemistry</topic><topic>Pigments, Biological - isolation & purification</topic><topic>Pigments, Biological - pharmacology</topic><topic>prodigiosin</topic><topic>Prodigiosin - analogs & derivatives</topic><topic>Prodigiosin - isolation & purification</topic><topic>Prodigiosin - pharmacology</topic><topic>Pseudoalteromonas</topic><topic>Pseudoalteromonas - chemistry</topic><topic>Spectrometry, Mass, Electrospray Ionization</topic><topic>Structural analysis</topic><topic>U937 Cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WANG, Yi</creatorcontrib><creatorcontrib>NAKAJIMA, Aya</creatorcontrib><creatorcontrib>HOSOKAWA, Kakushi</creatorcontrib><creatorcontrib>SOLIEV, Azamjon B.</creatorcontrib><creatorcontrib>OSAKA, Issey</creatorcontrib><creatorcontrib>ARAKAWA, Ryuichi</creatorcontrib><creatorcontrib>ENOMOTO, Keiichi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Bioscience, biotechnology, and biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WANG, Yi</au><au>NAKAJIMA, Aya</au><au>HOSOKAWA, Kakushi</au><au>SOLIEV, Azamjon B.</au><au>OSAKA, Issey</au><au>ARAKAWA, Ryuichi</au><au>ENOMOTO, Keiichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytotoxic Prodigiosin Family Pigments from Pseudoalteromonas sp. 1020R Isolated from the Pacific Coast of Japan</atitle><jtitle>Bioscience, biotechnology, and biochemistry</jtitle><addtitle>Biosci Biotechnol Biochem</addtitle><date>2012</date><risdate>2012</risdate><volume>76</volume><issue>6</issue><spage>1229</spage><epage>1232</epage><pages>1229-1232</pages><issn>0916-8451</issn><eissn>1347-6947</eissn><abstract>Pseudoalteromonas sp. 1020R, isolated from the Pacific coast of Japan, produces prodigiosin family pigments. Structural analysis indicated that these are prodigiosin (2-methyl-3-pentyl-prodiginine) and three other prodigiosin congeners which differ only in the lengths of the alkyl side chains. These compounds exhibited different extents of cytotoxicity against U937 leukemia cells, and cell death was accompanied by typical features of apoptosis.</abstract><cop>Tokyo</cop><pub>Japan Society for Bioscience, Biotechnology, and Agrochemistry</pub><pmid>22790952</pmid><doi>10.1271/bbb.110984</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Bioscience, biotechnology, and biochemistry, 2012, Vol.76 (6), p.1229-1232 |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Open Access Titles of Japan; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology apoptosis Apoptosis - drug effects Aquatic Organisms - chemistry Biochemistry Biological and medical sciences Biotechnology Caspase 3 - metabolism Cell death Coastal environments Congeners cytotoxicity DNA Fragmentation - drug effects Fundamental and applied biological sciences. Psychology Humans Japan Leukemias Magnetic Resonance Spectroscopy Pigments Pigments, Biological - chemistry Pigments, Biological - isolation & purification Pigments, Biological - pharmacology prodigiosin Prodigiosin - analogs & derivatives Prodigiosin - isolation & purification Prodigiosin - pharmacology Pseudoalteromonas Pseudoalteromonas - chemistry Spectrometry, Mass, Electrospray Ionization Structural analysis U937 Cells |
| title | Cytotoxic Prodigiosin Family Pigments from Pseudoalteromonas sp. 1020R Isolated from the Pacific Coast of Japan |
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