Cytotoxic Prodigiosin Family Pigments from Pseudoalteromonas sp. 1020R Isolated from the Pacific Coast of Japan

Pseudoalteromonas sp. 1020R, isolated from the Pacific coast of Japan, produces prodigiosin family pigments. Structural analysis indicated that these are prodigiosin (2-methyl-3-pentyl-prodiginine) and three other prodigiosin congeners which differ only in the lengths of the alkyl side chains. These...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2012, Vol.76 (6), p.1229-1232
Hauptverfasser:	WANG, Yi, NAKAJIMA, Aya, HOSOKAWA, Kakushi, SOLIEV, Azamjon B., OSAKA, Issey, ARAKAWA, Ryuichi, ENOMOTO, Keiichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology apoptosis Apoptosis - drug effects Aquatic Organisms - chemistry Biochemistry Biological and medical sciences Biotechnology Caspase 3 - metabolism Cell death Coastal environments Congeners cytotoxicity DNA Fragmentation - drug effects Fundamental and applied biological sciences. Psychology Humans Japan Leukemias Magnetic Resonance Spectroscopy Pigments Pigments, Biological - chemistry Pigments, Biological - isolation & purification Pigments, Biological - pharmacology prodigiosin Prodigiosin - analogs & derivatives Prodigiosin - isolation & purification Prodigiosin - pharmacology Pseudoalteromonas Pseudoalteromonas - chemistry Spectrometry, Mass, Electrospray Ionization Structural analysis U937 Cells
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Zusammenfassung:	Pseudoalteromonas sp. 1020R, isolated from the Pacific coast of Japan, produces prodigiosin family pigments. Structural analysis indicated that these are prodigiosin (2-methyl-3-pentyl-prodiginine) and three other prodigiosin congeners which differ only in the lengths of the alkyl side chains. These compounds exhibited different extents of cytotoxicity against U937 leukemia cells, and cell death was accompanied by typical features of apoptosis.
ISSN:	0916-8451 1347-6947
DOI:	10.1271/bbb.110984