Alpha-lipoic acid reduces peridural fibrosis after laminectomy of lumbar vertebrae in rabbits

Background Peridural fibrosis is an inevitable healing process causing failed back surgery syndrome after lumbar spinal operations. In this study, alpha-lipoic acid (ALA), reported to reduce fibrosis in liver, oral mucosa, and peritoneum, investigated as a potential candidate for prevention of peridural fibrosis. Method Twelve adult New Zealand white male rabbits were divided into control ( n = 5) and ALA groups ( n = 7). Laminectomy of lumbar spine was performed and ALA was applied on the exposed dura mater topically in ALA group. Results According to histological peridural grading, the ALA group (median grade 1) showed significantly less peridural fibrosis than the control group (median grade 3, p = 0.005). Conclusions ALA is a promising substance in the prevention of peridural fibrosis, especially in early preoperative and postoperative period.