The role of small GTPases in neuronal morphogenesis and polarity

The role of small GTPases in neuronal morphogenesis and polarity

The highly dynamic remodeling and cross talk of the microtubule and actin cytoskeleton support neuronal morphogenesis. Small RhoGTPases family members have emerged as crucial regulators of cytoskeletal dynamics. In this review we will comprehensively analyze findings that support the participation o...

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Veröffentlicht in:Cytoskeleton (Hoboken, N.J.) N.J.), 2012-07, Vol.69 (7), p.464-485
Hauptverfasser: Gonzalez-Billault, Christian, Muñoz-Llancao, Pablo, Henriquez, Daniel R., Wojnacki, José, Conde, Cecilia, Caceres, Alfredo
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cdc42
Cell Polarity
cytoskeleton dynamics
Humans
Models, Biological
Monomeric GTP-Binding Proteins - metabolism
Morphogenesis
neuronal polarity
Neurons - cytology
Neurons - enzymology
Rac1
RhoA
TC10
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Zusammenfassung:The highly dynamic remodeling and cross talk of the microtubule and actin cytoskeleton support neuronal morphogenesis. Small RhoGTPases family members have emerged as crucial regulators of cytoskeletal dynamics. In this review we will comprehensively analyze findings that support the participation of RhoA, Rac, Cdc42, and TC10 in different neuronal morphogenetic events ranging from migration to synaptic plasticity. We will specifically address the contribution of these GTPases to support neuronal polarity and axonal elongation. © 2012 Wiley Periodicals, Inc
ISSN:1949-3584
1949-3592
DOI:10.1002/cm.21034