Core-Shell Nanocapsules Stabilized by Single-Component Polymer and Nanoparticles for Magneto-Chemotherapy/Hyperthermia with Multiple Drugs

Iron‐oxide‐containing double emulsion capsules carrying both hydrophilic and hydrophobic therapeutic molecules can deliver drugs and energy on demand in vivo. Magneto‐chemotherapy/hyperthermia involves a burst‐like release of hydrophilic doxorubicin and hydrophobic paclitaxel, remotely triggered by...

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Veröffentlicht in:	Advanced materials (Weinheim) 2012-07, Vol.24 (27), p.3627-3632
Hauptverfasser:	Hu, Shang-Hsiu, Liao, Bang-Jie, Chiang, Chin-Sheng, Chen, Po-Jung, Chen, I-Wei, Chen, San-Yuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - administration & dosage Cell Line, Tumor double emulsions Doxorubicin - administration & dosage Emulsions - chemistry Ferric Compounds - chemistry HeLa Cells Humans Hydrophobic and Hydrophilic Interactions hyperthermia Hyperthermia, Induced iron oxide nanoparticles Magnetic Fields Mice nanocapsules Nanocapsules - chemistry Nanoparticles - chemistry Neoplasms - drug therapy Paclitaxel - administration & dosage Polymers - chemistry synergic therapy Transplantation, Heterologous
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Beschreibung
Zusammenfassung:	Iron‐oxide‐containing double emulsion capsules carrying both hydrophilic and hydrophobic therapeutic molecules can deliver drugs and energy on demand in vivo. Magneto‐chemotherapy/hyperthermia involves a burst‐like release of hydrophilic doxorubicin and hydrophobic paclitaxel, remotely triggered by a high frequency magnetic field, which also releases energy via internalized iron oxide nanoparticles, all contributing to cell kill.
ISSN:	0935-9648 1521-4095
DOI:	10.1002/adma.201201251