Cell Therapy in Chagas Cardiomyopathy (Chagas Arm of the Multicenter Randomized Trial of Cell Therapy in Cardiopathies Study): A Multicenter Randomized Trial

Cell Therapy in Chagas Cardiomyopathy (Chagas Arm of the Multicenter Randomized Trial of Cell Therapy in Cardiopathies Study): A Multicenter Randomized Trial

Previous studies suggested that transplantation of autologous bone marrow-derived mononuclear cells (BMNCs) improves heart function in chronic chagasic cardiomyopathy. We report the results of the first randomized trial of BMNC therapy in chronic chagasic cardiomyopathy. Patients 18 to 75 years of a...

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Veröffentlicht in:Circulation (New York, N.Y.) N.Y.), 2012-05, Vol.125 (20), p.2454-2461
Hauptverfasser: SANTOS, Ricardo Ribeiro Dos, RASSI, Salvador, SOARES, Milena B. P, CAMPOS DE CARVALHO, Antonio C, FEITOSA, Gilson, GRECCO, Oswaldo T, RASSI, Anis, DA CUNHA, Ademir B, DE CARVALHO, Valeria B, GUARITA-SOUZA, Luiz Cesar, OLIVEIRA, Wilson De, TURA, Bernardo R
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Aged
Biological and medical sciences
Blood and lymphatic vessels
Blood. Blood coagulation. Reticuloendothelial system
Bone Marrow Transplantation - methods
Cardiology. Vascular system
Chagas Cardiomyopathy - therapy
Chronic Disease
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Female
Follow-Up Studies
Humans
Injections, Intralesional
Male
Medical sciences
Middle Aged
Motor Activity
Pharmacology. Drug treatments
Quality of Life
Transplantation, Autologous
Treatment Failure
Ventricular Function, Left
Young Adult
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Zusammenfassung:Previous studies suggested that transplantation of autologous bone marrow-derived mononuclear cells (BMNCs) improves heart function in chronic chagasic cardiomyopathy. We report the results of the first randomized trial of BMNC therapy in chronic chagasic cardiomyopathy. Patients 18 to 75 years of age with chronic chagasic cardiomyopathy, New York Heart Association class II to IV heart failure, left ventricular ejection fraction (LVEF)
ISSN:0009-7322
1524-4539
DOI:10.1161/CIRCULATIONAHA.111.067785