Polycomb in Stem Cells: PRC1 Branches Out

Polycomb group proteins (PcGs) generate chromatin-modifying complexes that regulate gene expression. PcGs are categorized into two major groups, polycomb repressive complex 1 (PRC1) and 2 (PRC2), which have classically been thought to function together. Here we discuss recent data challenging this m...

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Veröffentlicht in:	Cell stem cell 2012-07, Vol.11 (1), p.16-21
Hauptverfasser:	Luis, Nuno Miguel, Morey, Lluis, Di Croce, Luciano, Benitah, Salvador Aznar
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Stem Cells - metabolism Animals Biological and medical sciences Cell differentiation, maturation, development, hematopoiesis Cell physiology Embryonic Stem Cells - metabolism Fundamental and applied biological sciences. Psychology Humans Intracellular Signaling Peptides and Proteins - metabolism Molecular and cellular biology Multiprotein Complexes - metabolism Polycomb-Group Proteins Repressor Proteins - metabolism Stem Cells - metabolism
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Zusammenfassung:	Polycomb group proteins (PcGs) generate chromatin-modifying complexes that regulate gene expression. PcGs are categorized into two major groups, polycomb repressive complex 1 (PRC1) and 2 (PRC2), which have classically been thought to function together. Here we discuss recent data challenging this model indicating that the distinct subunit composition of PRC1 confers specific and nonoverlapping functions in embryonic and adult stem cells.
ISSN:	1934-5909 1875-9777 1875-9777
DOI:	10.1016/j.stem.2012.06.005