Glycine blocks the regulatory volume response of mouse oocytes to hypoosmotic stress

The role of glycine in the compensatory response of an embryonic cell to hypotonic stress remains poorly understood, and only single papers are devoted to RVD regulation in the mature oocytes, the immediate precursor of early embryogenesis. A study shows that glycine present at a physiological concentration (10 mM) in the extracellular space blocks the development of RVD in the oocyte. The effect is similar to the non osmotic effect of ATP, an inhibitor of VSOAC. A decrease in the concentration of the amino acid to the submillimolar level does not recover the compensatory reaction.