A Prospective, Split‐Face, Randomized, Comparative Study of Safety and 12‐Month Longevity of Three Formulations of Hyaluronic Acid Dermal Filler for Treatment of Nasolabial Folds

Background Data regarding several hyaluronic acids (HAs) used identically for facial tissue augmentation have heretofore been unavailable. Objectives This prospective, split‐face, randomized, two‐armed study sought to determine the long‐term safety and effectiveness of three HAs (HA‐1 (Belotero Basi...

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Veröffentlicht in:Dermatologic surgery 2012-07, Vol.38 (7pt2), p.1143-1150
Hauptverfasser: Prager, Welf, Wissmueller, Esther, Havermann, Isabel, Bee, Eva K., Howell, David J., Zschocke, Ina, Simon, Jeannette
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Sprache:eng
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Zusammenfassung:Background Data regarding several hyaluronic acids (HAs) used identically for facial tissue augmentation have heretofore been unavailable. Objectives This prospective, split‐face, randomized, two‐armed study sought to determine the long‐term safety and effectiveness of three HAs (HA‐1 (Belotero Basic/Balance), HA‐2 (Restylane), and HA‐3 (Juvéderm Ultra 3/Juvéderm Ultra Plus XC) in the treatment of nasolabial folds (NLFs). Methods Twenty participants in Arm A received HA‐1 in one NLF and HA‐2 in the other. In Arm B, 20 participants received HA‐1 in one NLF and HA‐3 in the other. Injection was at visit 2, with follow‐up visits at 1, 6, 9, and 12 months. Mean volume of HA was slightly
ISSN:1076-0512
1524-4725
DOI:10.1111/j.1524-4725.2012.02468.x