Synthesis of α,γ-Peptide Hybrids by Selective Conversion of Glutamic Acid Units

Synthesis of α,γ-Peptide Hybrids by Selective Conversion of Glutamic Acid Units

The site-selective modification of small peptides at a glutamate residue allows the ready preparation of α,γ-hybrids. In this way, a single peptide can be transformed into a variety of hybrid derivatives. The process takes place under very mild conditions, and good global yields are obtained.

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Organic letters 2012-07, Vol.14 (13), p.3542-3545
Hauptverfasser: Saavedra, Carlos J, Boto, Alicia, Hernández, Rosendo
Format: Artikel
Sprache:eng
Schlagworte:
Glutamic Acid - chemistry
Molecular Conformation
Peptides - chemical synthesis
Peptides - chemistry
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The site-selective modification of small peptides at a glutamate residue allows the ready preparation of α,γ-hybrids. In this way, a single peptide can be transformed into a variety of hybrid derivatives. The process takes place under very mild conditions, and good global yields are obtained.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol301552c