Time to individualize duration of parenteral anticoagulation in pulmonary thromboembolism?

[...]giving oral anticoagulant (OAC) from the first day may be somewhat counterproductive (at least theoretically) because of well-known prothrombotic action of warfarin in the first days of administration. Namely, heparin not only acts more rapidly than OAC, but it also has a better antithrombotic...

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Veröffentlicht in:The American journal of emergency medicine 2012-07, Vol.30 (6), p.1004-1006
1. Verfasser: Koracevic, Goran P., MD, PhD
Format: Artikel
Sprache:eng
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Zusammenfassung:[...]giving oral anticoagulant (OAC) from the first day may be somewhat counterproductive (at least theoretically) because of well-known prothrombotic action of warfarin in the first days of administration. Namely, heparin not only acts more rapidly than OAC, but it also has a better antithrombotic effect [12-14]. [...]low-molecular-weight heparin (LMWH) is preferred to unfractionated heparin (UFH) for the initial treatment of acute nonmassive PTE Antithrombotic Therapy for Venous Thromboembolic Disease- American College of Chest Physicians Guidelines (8th Edition) recommendation grade 1A) [15].
ISSN:0735-6757
1532-8171
DOI:10.1016/j.ajem.2012.03.016