AMP‐activated protein kinase: ‘a cup of tea' against cholesterol‐induced neurotoxicity

Disturbances in brain cholesterol metabolism have been linked to Alzheimer's disease (AD) pathology. A high‐cholesterol diet increases fibrillar amyloid β peptide (Aβ) deposition, inflammation, and apoptosis that eventually results in neurodegeneration and learning and memory impairments. In the October 2010 issue of The Journal of Pathology, Lu and colleagues provided a novel and interesting mechanism that explains how quercetin, a flavonoid found at high concentrations in green and black teas, may help to protect against cholesterol‐induced neurotoxicity through activation of AMP‐activated protein kinase (AMPK), a metabolic energy gauge. Further work will be necessary to address whether AMPK may be a potential target to combat neurodegenerative diseases. Copyright © 2010 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. Invited Commentary for Lu et al. Quercetin activates AMP‐activated protein kinase by reducing PP2C expression protecting old mouse brain against high cholesterol‐induced neurotoxicity, Journal of Pathology, 2010; 222 199–212.