Watching Water Migration around a Peptide Bond

Watching Water Migration around a Peptide Bond

A long and winding road: The motion of a single water ligand around a peptide bond in acetanilide was probed in real time by time‐resolved IR spectroscopy. Triggered by photoionization, the H2O ligand is released from the CO site of the peptide linkage and trapped after a migration time of 5 ps at t...

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Veröffentlicht in:Angewandte Chemie International Edition 2012-07, Vol.51 (27), p.6604-6607
Hauptverfasser: Tanabe, Kohei, Miyazaki, Mitsuhiko, Schmies, Matthias, Patzer, Alexander, Schütz, Markus, Sekiya, Hiroshi, Sakai, Makoto, Dopfer, Otto, Fujii, Masaaki
Format: Artikel
Sprache:eng
Schlagworte:
hydration
Hydrogen Bonding
hydrogen bonds
IR spectroscopy
isomerization
Models, Chemical
peptides
Peptides - chemistry
Peptides - metabolism
Permeability
Spectrophotometry, Infrared
Water - chemistry
Water - metabolism
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Zusammenfassung:A long and winding road: The motion of a single water ligand around a peptide bond in acetanilide was probed in real time by time‐resolved IR spectroscopy. Triggered by photoionization, the H2O ligand is released from the CO site of the peptide linkage and trapped after a migration time of 5 ps at the NH site of the same peptide bond (see picture).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201203296