Total and High-Density Lipoprotein Cholesterol and Stroke Risk

The association of total and high-density lipoprotein (HDL) cholesterol with stroke risk is unclear, especially regarding hemorrhagic stroke. We prospectively investigated the associations of serum total and HDL cholesterol and total/HDL cholesterol ratio with total and type-specific stroke incidenc...

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Veröffentlicht in:	Stroke (1970) 2012-07, Vol.43 (7), p.1768-1774
Hauptverfasser:	YURONG ZHANG, TUOMILEHTO, Jaakko, JOUSILAHTI, Pekka, YUJIE WANG, ANTIKAINEN, Riitta, GANG HU
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biological and medical sciences Cholesterol - blood Cholesterol, HDL - blood Cohort Studies Female Finland - epidemiology Follow-Up Studies Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Male Medical sciences Middle Aged Nervous system (semeiology, syndromes) Neurology Prospective Studies Risk Factors Stroke - blood Stroke - epidemiology Surveys and Questionnaires Vascular diseases and vascular malformations of the nervous system
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Zusammenfassung:	The association of total and high-density lipoprotein (HDL) cholesterol with stroke risk is unclear, especially regarding hemorrhagic stroke. We prospectively investigated the associations of serum total and HDL cholesterol and total/HDL cholesterol ratio with total and type-specific stroke incidence among 58,235 Finnish people aged 25 to 74 years and free of coronary heart disease and stroke at baseline. During a mean follow-up period of 20.1 years, 3914 participants developed stroke events (3085 ischemic, 497 intracerebral hemorrhage, and 332 subarachnoid hemorrhage). The multivariable-adjusted hazard ratios at different levels of total cholesterol (
ISSN:	0039-2499 1524-4628
DOI:	10.1161/strokeaha.111.646778