Hortonones A to C, Hydroazulenones from the Genus Hortonia

The new hexahydroazulenones hortonones A (1) to C (3) were isolated from the leaves of three representative species of the endemic Sri Lankan genus Hortonia that belongs to the family Monimiaceae. Hortonones A (1) and B (2) have the unprecedented rearranged hortonane sesquiterpenoid carbon skeleton,...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2012-06, Vol.75 (6), p.1189-1191
Hauptverfasser:	Carr, Gavin, Williams, David E, Ratnayake, Rukmal, Bandara, Ratnayake, Wijesundara, Siril, Tarling, Tamsin, Balgi, Aruna D, Roberge, Michel, Andersen, Raymond J, Karunaratne, Veranja
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Breast Neoplasms Diterpenes - chemistry Diterpenes - isolation & purification Diterpenes - pharmacology Drug Screening Assays, Antitumor Female Humans Molecular Structure Monimiaceae - chemistry Plant Leaves - chemistry Sri Lanka
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Zusammenfassung:	The new hexahydroazulenones hortonones A (1) to C (3) were isolated from the leaves of three representative species of the endemic Sri Lankan genus Hortonia that belongs to the family Monimiaceae. Hortonones A (1) and B (2) have the unprecedented rearranged hortonane sesquiterpenoid carbon skeleton, and hortonone C (3) has the unprecedented rearranged and degraded 13-norhortonane skeleton. Hortonone C (3) exhibited in vitro cytotoxicity against human breast cancer MCF-7 cells at 5 μg/mL.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np200927k