A comparison of the neuroendocrine mechanisms underlying the initiation of the preovulatory LH surge in the human, Old World monkey and rodent

Highlights ► Important species differences exist in the neural control of the LH surge. ► The significance of the GnRH surge has diminished during the course of evolution. ► GnRH pulse generation alone may provide the hypothalamic drive for human ovulation.

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Veröffentlicht in:Frontiers in neuroendocrinology 2012-04, Vol.33 (2), p.160-168
1. Verfasser: Plant, Tony M
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description Highlights ► Important species differences exist in the neural control of the LH surge. ► The significance of the GnRH surge has diminished during the course of evolution. ► GnRH pulse generation alone may provide the hypothalamic drive for human ovulation.
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source MEDLINE; Elsevier ScienceDirect Journals
subjects Animals
Cercopithecidae - blood
Cercopithecidae - physiology
Endocrinology & Metabolism
Estradiol positive feedback
Female
Follicular Phase - blood
Follicular Phase - metabolism
GnRH pulse generator
Higher primate
Humans
Hypothalamus - anatomy & histology
Hypothalamus - metabolism
Hypothalamus - physiology
KISS1/KISS1R
Kisspeptin
KNDy neurons
Luteinizing Hormone - blood
Luteinizing Hormone - secretion
Menstrual cycle
Models, Biological
Neurokinin B
Neurosecretory Systems - physiology
Preovulatory LH surge
Rodentia - blood
Rodentia - physiology
Signal Transduction - physiology
title A comparison of the neuroendocrine mechanisms underlying the initiation of the preovulatory LH surge in the human, Old World monkey and rodent
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