A comparison of the neuroendocrine mechanisms underlying the initiation of the preovulatory LH surge in the human, Old World monkey and rodent
Highlights ► Important species differences exist in the neural control of the LH surge. ► The significance of the GnRH surge has diminished during the course of evolution. ► GnRH pulse generation alone may provide the hypothalamic drive for human ovulation.
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Veröffentlicht in: | Frontiers in neuroendocrinology 2012-04, Vol.33 (2), p.160-168 |
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container_title | Frontiers in neuroendocrinology |
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description | Highlights ► Important species differences exist in the neural control of the LH surge. ► The significance of the GnRH surge has diminished during the course of evolution. ► GnRH pulse generation alone may provide the hypothalamic drive for human ovulation. |
doi_str_mv | 10.1016/j.yfrne.2012.02.002 |
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blood</topic><topic>Cercopithecidae - physiology</topic><topic>Endocrinology & Metabolism</topic><topic>Estradiol positive feedback</topic><topic>Female</topic><topic>Follicular Phase - blood</topic><topic>Follicular Phase - metabolism</topic><topic>GnRH pulse generator</topic><topic>Higher primate</topic><topic>Humans</topic><topic>Hypothalamus - anatomy & histology</topic><topic>Hypothalamus - metabolism</topic><topic>Hypothalamus - physiology</topic><topic>KISS1/KISS1R</topic><topic>Kisspeptin</topic><topic>KNDy neurons</topic><topic>Luteinizing Hormone - blood</topic><topic>Luteinizing Hormone - secretion</topic><topic>Menstrual cycle</topic><topic>Models, Biological</topic><topic>Neurokinin B</topic><topic>Neurosecretory Systems - physiology</topic><topic>Preovulatory LH surge</topic><topic>Rodentia - blood</topic><topic>Rodentia - physiology</topic><topic>Signal Transduction - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Plant, Tony M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - 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source | MEDLINE; Elsevier ScienceDirect Journals |
subjects | Animals Cercopithecidae - blood Cercopithecidae - physiology Endocrinology & Metabolism Estradiol positive feedback Female Follicular Phase - blood Follicular Phase - metabolism GnRH pulse generator Higher primate Humans Hypothalamus - anatomy & histology Hypothalamus - metabolism Hypothalamus - physiology KISS1/KISS1R Kisspeptin KNDy neurons Luteinizing Hormone - blood Luteinizing Hormone - secretion Menstrual cycle Models, Biological Neurokinin B Neurosecretory Systems - physiology Preovulatory LH surge Rodentia - blood Rodentia - physiology Signal Transduction - physiology |
title | A comparison of the neuroendocrine mechanisms underlying the initiation of the preovulatory LH surge in the human, Old World monkey and rodent |
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