A comparison of the neuroendocrine mechanisms underlying the initiation of the preovulatory LH surge in the human, Old World monkey and rodent

Highlights ► Important species differences exist in the neural control of the LH surge. ► The significance of the GnRH surge has diminished during the course of evolution. ► GnRH pulse generation alone may provide the hypothalamic drive for human ovulation.

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Bibliographische Detailangaben
Veröffentlicht in:	Frontiers in neuroendocrinology 2012-04, Vol.33 (2), p.160-168
1. Verfasser:	Plant, Tony M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cercopithecidae - blood Cercopithecidae - physiology Endocrinology & Metabolism Estradiol positive feedback Female Follicular Phase - blood Follicular Phase - metabolism GnRH pulse generator Higher primate Humans Hypothalamus - anatomy & histology Hypothalamus - metabolism Hypothalamus - physiology KISS1/KISS1R Kisspeptin KNDy neurons Luteinizing Hormone - blood Luteinizing Hormone - secretion Menstrual cycle Models, Biological Neurokinin B Neurosecretory Systems - physiology Preovulatory LH surge Rodentia - blood Rodentia - physiology Signal Transduction - physiology
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Beschreibung
Zusammenfassung:	Highlights ► Important species differences exist in the neural control of the LH surge. ► The significance of the GnRH surge has diminished during the course of evolution. ► GnRH pulse generation alone may provide the hypothalamic drive for human ovulation.
ISSN:	0091-3022 1095-6808
DOI:	10.1016/j.yfrne.2012.02.002