Oestrogen's regulation of fat metabolism during exercise and gender specific effects

Highlights ► In muscle oestrogen increases the expression and protein content of PPARα and PPARδ⋅ ► Oestrogen's direct/indirect genomic action increases LCFA transport and oxidation. ► During exercise, oestrogen promotes the mobilisation of adipose stores. ► Oestrogen increases gene expression...

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Veröffentlicht in:	Current opinion in pharmacology 2012-06, Vol.12 (3), p.363-371
Hauptverfasser:	Oosthuyse, Tanja, Bosch, Andrew N
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes, White - drug effects Adipocytes, White - metabolism Animals Estrogen Receptor alpha - agonists Estrogen Receptor alpha - metabolism Estrogens - metabolism Estrogens - pharmacology Exercise Female Gene Expression Regulation - drug effects Heat-Shock Proteins - genetics Heat-Shock Proteins - metabolism Humans Internal Medicine Lipid Metabolism - drug effects Lipolysis - drug effects Male Medical Education Motor Activity Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Organ Specificity Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha Sex Characteristics Signal Transduction - drug effects Sterol Esterase - genetics Sterol Esterase - metabolism Transcription Factors - genetics Transcription Factors - metabolism
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Beschreibung
Zusammenfassung:	Highlights ► In muscle oestrogen increases the expression and protein content of PPARα and PPARδ⋅ ► Oestrogen's direct/indirect genomic action increases LCFA transport and oxidation. ► During exercise, oestrogen promotes the mobilisation of adipose stores. ► Oestrogen increases gene expression for IMCL storage to enhance LCFA availability. ► Oestrogen and catechol-oestrogen metabolite activates AMPK via non-genomic means.
ISSN:	1471-4892 1471-4973
DOI:	10.1016/j.coph.2012.02.008