TRP channels in normal and dystrophic skeletal muscle
Highlights ► TRP proteins constitute non-selective calcium-permeable channels. ► The most consistently found isoforms in skeletal muscle are TRPC1, C3, C6, TRPV2 and V4, TRPM4 and M7. ► In this review, we discuss the gating mechanisms of these TRP channels, their pharmacological profiles and their f...
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| Veröffentlicht in: | Current opinion in pharmacology 2012-06, Vol.12 (3), p.326-334 |
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| creator | Gailly, Philippe |
| description | Highlights ► TRP proteins constitute non-selective calcium-permeable channels. ► The most consistently found isoforms in skeletal muscle are TRPC1, C3, C6, TRPV2 and V4, TRPM4 and M7. ► In this review, we discuss the gating mechanisms of these TRP channels, their pharmacological profiles and their functions in normal muscle. ► Their possible involvement in Duchenne muscular dystrophy is also summarized. |
| doi_str_mv | 10.1016/j.coph.2012.01.018 |
| format | Article |
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| fulltext | fulltext |
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| ispartof | Current opinion in pharmacology, 2012-06, Vol.12 (3), p.326-334 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Animals Excitation Contraction Coupling Humans Internal Medicine Medical Education Muscle Fibers, Skeletal - metabolism Muscle, Skeletal - metabolism Muscular Dystrophies - metabolism Transient Receptor Potential Channels - metabolism TRPM Cation Channels - metabolism TRPV Cation Channels - metabolism |
| title | TRP channels in normal and dystrophic skeletal muscle |
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